Calcb MGI Mouse Gene Detail - MGI:2151254 - calcitonin-related polypeptide, beta

Symbol

Calcb
Name

calcitonin-related polypeptide, beta
Synonyms

Calc2, CGRP2

Feature Type

protein coding gene
IDs

MGI:2151254
NCBI Gene: 116903
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr7:114317878-114322600 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 60.19 cM, cytoband F3
Mapping Data

1 experiment

SNPs within 2kb

263 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2151254	protein coding gene	Chr7:114315790-114322603 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0032885	protein coding gene	Chr7:118397894-118402647 (+)
A/J	MGP_AJ_G0032868	protein coding gene	Chr7:115425542-115430825 (+)
AKR/J	MGP_AKRJ_G0032800	protein coding gene	Chr7:118343386-118348200 (+)
BALB/cJ	MGP_BALBcJ_G0032873	protein coding gene	Chr7:115127073-115131790 (+)
C3H/HeJ	MGP_C3HHeJ_G0032583	protein coding gene	Chr7:118307526-118312246 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0033379	protein coding gene	Chr7:123147795-123152526 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030351	protein coding gene	Chr7:116947070-116951753 (+)
CAST/EiJ	MGP_CASTEiJ_G0031911	protein coding gene	Chr7:109956279-109962281 (+)
CBA/J	MGP_CBAJ_G0032556	protein coding gene	Chr7:127263530-127270169 (+)
DBA/2J	MGP_DBA2J_G0032708	protein coding gene	Chr7:113472921-113477637 (+)
FVB/NJ	MGP_FVBNJ_G0032661	protein coding gene	Chr7:113339718-113344484 (+)
LP/J	MGP_LPJ_G0032802	protein coding gene	Chr7:119899553-119904297 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032693	protein coding gene	Chr7:128861783-128866496 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033399	protein coding gene	Chr7:117319471-117324203 (+)
PWK/PhJ	MGP_PWKPhJ_G0031619	protein coding gene	Chr7:106351404-106356108 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0031466	protein coding gene	Chr7:104060268-104064969 (+)
WSB/EiJ	MGP_WSBEiJ_G0032024	protein coding gene	Chr7:118192971-118197680 (+)

Human Ortholog

CALCB, calcitonin related polypeptide beta

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CALCB, calcitonin related polypeptide beta
Synonyms

CALC2, CGRP2, CGRP-II
Links

HGNC:1438

NCBI Gene ID: 797

neXtProt AC: NX_P10092

UniProt: P10092
Chr Location

11p15.2; chr11:14904997-15082342 (+) GRCh38

MGI Vertebrate Homology

Calcb stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CALCB
Gene Tree

Calcb

Diseases

2 with human CALCA associations

				Human Disease	Mouse Models
				migraine IDs migraine DOID:6364 DOID:12437 ICD10CM:G43 ICD9CM:346 ICD9CM:346.9 MESH:D008881 NCI:C89715 OMIM:157300 UMLS_CUI:C0042331 UMLS_CUI:C0149931
				osteoporosis IDs osteoporosis DOID:11476 EFO:0003882 ICD10CM:M81.0 ICD9CM:733.0 ICD9CM:733.00 MESH:D010024 NCI:C3298 OMIM:166710 UMLS_CUI:C0029456

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

7 phenotypes from 1 allele in 1 genetic background
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Endonuclease-mediated

6
Radiation induced

1
Targeted

3
Genomic Mutations

1 involving Calcb
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

14 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

7
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

894
Tissues

160
cDNA Data

8
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas

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All Sequences

42
RefSeq

8
UniProt

4
CCDS

CCDS21764.1

Ensembl

ENSMUSG00000030666 (Evidence)
NCBI Gene

116903

			Length	Strain/Species	Flank
genomic	ENSMUSG00000030666	Ensembl Gene Model \| MGI Sequence Detail	4723	C57BL/6J	± kb
transcript	ENSMUST00000182816	Ensembl \| MGI Sequence Detail	706	Not Applicable
polypeptide	ENSMUSP00000138713	Ensembl \| MGI Sequence Detail	156	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000004969 calcitonin gene-related peptide 2

(term hierarchy)
InterPro Domains

IPR021116 Calcitonin/adrenomedullin

IPR018360 Calcitonin, conserved site

IPR015476 Calcitonin gene-related peptide

IPR021117 Calcitonin-like

IPR001693 Calcitonin peptide-like

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All nucleic 10

cDNA 8

Primer pair 1

Other 1

Microarray probesets 2

Summaries

All 50

Developmental Gene Expression 6

Gene Ontology 4

Phenotypes 19
Earliest

J:61682 Hagiwara N, et al., Sox6 is a candidate gene for p100H myopathy, heart block, and sudden neonatal death. Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):4180-5
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Calcb:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr68654	Chr7:114316514-114316525 (+)	-1,358 bp
Tssr68655	Chr7:114316528-114316540 (+)	-1,344 bp
Tssr68656	Chr7:114316564-114316581 (+)	-1,305 bp
Tssr68657	Chr7:114316664-114316683 (+)	-1,204 bp
Tssr68658	Chr7:114317878-114317896 (+)	9 bp
Tssr68659	Chr7:114318821-114318856 (+)	961 bp
Tssr68660	Chr7:114321426-114321443 (+)	3,557 bp
Tssr68661	Chr7:114321479-114321494 (+)	3,609 bp
Tssr68662	Chr7:114321686-114321718 (+)	3,824 bp
Tssr68663	Chr7:114322016-114322030 (+)	4,145 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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