Tgs1 MGI Mouse Gene Detail - MGI:2151797 - trimethylguanosine synthase 1

Symbol

Tgs1
Name

trimethylguanosine synthase 1
Synonyms

D4Ertd800e, Ncoa6ip, Pimt

Feature Type

protein coding gene
IDs

MGI:2151797
NCBI Gene: 116940
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr4:3574875-3616619 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 1.99 cM, cytoband A1
Mapping Data

3 experiments

SNPs within 2kb

823 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2151797	protein coding gene	Chr4:3574875-3616624 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0028022	protein coding gene	Chr4:38558-80859 (+)
A/J	MGP_AJ_G0027980	protein coding gene	Chr4:52260-95356 (+)
AKR/J	MGP_AKRJ_G0027946	protein coding gene	Chr4:41970-83221 (+)
BALB/cJ	MGP_BALBcJ_G0027992	protein coding gene	Chr4:33546-75712 (+)
C3H/HeJ	MGP_C3HHeJ_G0027722	protein coding gene	Chr4:197163-237532 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028435	protein coding gene	Chr4:120554-167216 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025779	protein coding gene	Chr4:33494-75132 (+)
CAST/EiJ	MGP_CASTEiJ_G0027175	protein coding gene	Chr4:48206-89738 (+)
CBA/J	MGP_CBAJ_G0027697	protein coding gene	Chr4:39833-80803 (+)
DBA/2J	MGP_DBA2J_G0027837	protein coding gene	Chr4:51147-92187 (+)
FVB/NJ	MGP_FVBNJ_G0027804	protein coding gene	Chr4:24933-65949 (+)
LP/J	MGP_LPJ_G0027948	protein coding gene	Chr4:90069-132843 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027837	protein coding gene	Chr4:190164-239882 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028494	protein coding gene	Chr4:46573-89477 (+)
PWK/PhJ	MGP_PWKPhJ_G0026898	protein coding gene	Chr4:188487-230479 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026727	protein coding gene	Chr4:39698-81007 (+)
WSB/EiJ	MGP_WSBEiJ_G0027255	protein coding gene	Chr4:144775-185684 (+)

Human Ortholog

TGS1, trimethylguanosine synthase 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TGS1, trimethylguanosine synthase 1
Synonyms

NCOA6IP, PIMT, PIPMT
Links

HGNC:17843

NCBI Gene ID: 96764

neXtProt AC: NX_Q96RS0

UniProt: Q96RS0
Chr Location

8q12.1; chr8:55773446-55826445 (+) GRCh38

MGI Vertebrate Homology

Tgs1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: TGS1
Gene Tree

Tgs1

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Phenotype Summary

9 phenotypes from 2 alleles in 2 genetic backgrounds
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Gene trapped

3
Targeted

5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

31 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null mutation display complete lethality around implantation with embryonic growth arrest, impaired hatching from the zona pellucida, and increased apoptosis. Null MEFs display G2 arrest.

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All GO Annotations

14
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

777
Tissues

45
cDNA Data

103
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tgs1

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All Sequences

51
RefSeq

4
UniProt

2
CCDS

CCDS17938.1

Ensembl

ENSMUSG00000028233 (Evidence)
NCBI Gene

116940

			Length	Strain/Species	Flank
genomic	ENSMUSG00000028233	Ensembl Gene Model \| MGI Sequence Detail	41745	C57BL/6J	± kb
transcript	ENSMUST00000052712	Ensembl \| MGI Sequence Detail	4327	Not Applicable
polypeptide	ENSMUSP00000054112	Ensembl \| MGI Sequence Detail	853	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000016300 trimethylguanosine synthase

(term hierarchy)
EC

2.1.1.-
InterPro Domains

IPR019012 RNA cap guanine-N2 methyltransferase

IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily

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All nucleic 106

cDNA 103

Primer pair 3

Microarray probesets 7

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MGI:1289226

Summaries

All 41

Developmental Gene Expression 4

Gene Ontology 6

Phenotypes 8
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:329543 Blandino-Rosano M, et al., Trimethylguanosine synthase 1 is a novel regulator of pancreatic beta-cell mass and function. J Biol Chem. 2022 Jan 15;298(3):101592

TSS for Tgs1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr36327	Chr4:3574855-3574871 (+)	-12 bp
Tssr36328	Chr4:3574872-3574913 (+)	18 bp
Tssr36329	Chr4:3574917-3574933 (+)	50 bp
Tssr36330	Chr4:3574937-3574955 (+)	71 bp
Tssr36331	Chr4:3574958-3574970 (+)	89 bp
Tssr36332	Chr4:3574984-3574993 (+)	114 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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