Actre4 QTL Detail

Summary

• Symbol
  Actre4
• Name
  activity response to ethanol 4
• Synonyms
  Actre4q

• Feature Type
  QTL
• IDs
  MGI:2151939
  NCBI Gene: 117077
• Candidate Genes
  11 Genes

Location &
Maps

• Sequence Map
  Chr2:112024987-128173821 bp

  From MGI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 2, 59.40 cM (cM position of peak correlated region/marker)
• Mapping Data
  2 experiments

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  1 phenotype reference
  

• All Mutations and Alleles
  1
• QTL
  1
• Find Mice (IMSR)
  0 strains or lines available

Sequences &
Gene Models

• NCBI Gene
  117077

References

• Summaries
  All 4

  Phenotypes 1
• Earliest
  J:71081 Demarest K, et al., Further characterization and high-resolution mapping of quantitative trait loci for ethanol-induced locomotor activity. Behav Genet. 2001 Jan;31(1):79-91
• Latest
  J:98595 Kerns RT, et al., Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. J Neurosci. 2005 Mar 2;25(9):2255-66

Candidate Genes for Actre4:

Gene	Genome Location (GRCm39)	Reference	QTL Note
Actc1	Chr2:113877763-113883356 (-)	J:98595	Microarray analysis was used to identify genes showing alcohol-induced differential expression between inbred strains C57BL/6J and DBA/2J. These genes were then correlated to alcohol-related QTLs to identify potential candidate genes. The experiment involved identifying genes expressed differentially in alcohol-induced and non-induced animals but the following list of candidate genes are only for alcohol-induced states. On mouse Chromosome 2, several candidate genes were identified for Actre2 at 48 cM,Actre3 at 63 cM, Actre4 at 65 cM, and Alcp1 at 37 cM. Candidate genes for Actre2 are Dlx1 (44 cM), Frzb (49.75 cM), D2Ertd391e, and Kai1 (49.6 cM). Candidate genes for Actre3 and Actre4 are Bdnf (62 cM) and Actc1 (64 cM), respectively. Candidate genes forAlcp1 are Pbx3 (22 cM), Hspa5 (22.5 cM), Rprm, Pkp4, and March7 (formerly Axot).
Atg13	Chr2:91504963-91540921 (-)	J:98595	Microarray analysis was used to identify genes showing alcohol-induced differential expression between inbred strains C57BL/6J and DBA/2J. These genes were then correlated to alcohol-related QTLs to identify potential candidate genes. The experiment involved identifying genes expressed differentially in alcohol-induced and non-induced animals but the following list of candidate genes are only for alcohol-induced states. On mouse Chromosome 2, several candidate genes were identified for Actre2 at 48 cM,Actre3 at 63 cM, Actre4 at 65 cM, and Alcp1 at 37 cM. Candidate genes for Actre2 are Dlx1 (44 cM), Frzb (49.75 cM), D2Ertd391e, and Kai1 (49.6 cM). Candidate genes for Actre3 and Actre4 are Bdnf (62 cM) and Actc1 (64 cM), respectively. Candidate genes forAlcp1 are Pbx3 (22 cM), Hspa5 (22.5 cM), Rprm, Pkp4, and March7 (formerly Axot).
Bdnf	Chr2:109505045-109557352 (+)	J:98595	Microarray analysis was used to identify genes showing alcohol-induced differential expression between inbred strains C57BL/6J and DBA/2J. These genes were then correlated to alcohol-related QTLs to identify potential candidate genes. The experiment involved identifying genes expressed differentially in alcohol-induced and non-induced animals but the following list of candidate genes are only for alcohol-induced states. On mouse Chromosome 2, several candidate genes were identified for Actre2 at 48 cM,Actre3 at 63 cM, Actre4 at 65 cM, and Alcp1 at 37 cM. Candidate genes for Actre2 are Dlx1 (44 cM), Frzb (49.75 cM), D2Ertd391e, and Kai1 (49.6 cM). Candidate genes for Actre3 and Actre4 are Bdnf (62 cM) and Actc1 (64 cM), respectively. Candidate genes forAlcp1 are Pbx3 (22 cM), Hspa5 (22.5 cM), Rprm, Pkp4, and March7 (formerly Axot).
Cd82	Chr2:93249447-93293295 (-)	J:98595	Microarray analysis was used to identify genes showing alcohol-induced differential expression between inbred strains C57BL/6J and DBA/2J. These genes were then correlated to alcohol-related QTLs to identify potential candidate genes. The experiment involved identifying genes expressed differentially in alcohol-induced and non-induced animals but the following list of candidate genes are only for alcohol-induced states. On mouse Chromosome 2, several candidate genes were identified for Actre2 at 48 cM,Actre3 at 63 cM, Actre4 at 65 cM, and Alcp1 at 37 cM. Candidate genes for Actre2 are Dlx1 (44 cM), Frzb (49.75 cM), D2Ertd391e, and Kai1 (49.6 cM). Candidate genes for Actre3 and Actre4 are Bdnf (62 cM) and Actc1 (64 cM), respectively. Candidate genes forAlcp1 are Pbx3 (22 cM), Hspa5 (22.5 cM), Rprm, Pkp4, and March7 (formerly Axot).
Dlx1	Chr2:71358457-71364325 (+)	J:98595	Microarray analysis was used to identify genes showing alcohol-induced differential expression between inbred strains C57BL/6J and DBA/2J. These genes were then correlated to alcohol-related QTLs to identify potential candidate genes. The experiment involved identifying genes expressed differentially in alcohol-induced and non-induced animals but the following list of candidate genes are only for alcohol-induced states. On mouse Chromosome 2, several candidate genes were identified for Actre2 at 48 cM,Actre3 at 63 cM, Actre4 at 65 cM, and Alcp1 at 37 cM. Candidate genes for Actre2 are Dlx1 (44 cM), Frzb (49.75 cM), D2Ertd391e, and Kai1 (49.6 cM). Candidate genes for Actre3 and Actre4 are Bdnf (62 cM) and Actc1 (64 cM), respectively. Candidate genes forAlcp1 are Pbx3 (22 cM), Hspa5 (22.5 cM), Rprm, Pkp4, and March7 (formerly Axot).
Frzb	Chr2:80242314-80277740 (-)	J:98595	Microarray analysis was used to identify genes showing alcohol-induced differential expression between inbred strains C57BL/6J and DBA/2J. These genes were then correlated to alcohol-related QTLs to identify potential candidate genes. The experiment involved identifying genes expressed differentially in alcohol-induced and non-induced animals but the following list of candidate genes are only for alcohol-induced states. On mouse Chromosome 2, several candidate genes were identified for Actre2 at 48 cM,Actre3 at 63 cM, Actre4 at 65 cM, and Alcp1 at 37 cM. Candidate genes for Actre2 are Dlx1 (44 cM), Frzb (49.75 cM), D2Ertd391e, and Kai1 (49.6 cM). Candidate genes for Actre3 and Actre4 are Bdnf (62 cM) and Actc1 (64 cM), respectively. Candidate genes forAlcp1 are Pbx3 (22 cM), Hspa5 (22.5 cM), Rprm, Pkp4, and March7 (formerly Axot).
Hspa5	Chr2:34662102-34666541 (+)	J:98595	Microarray analysis was used to identify genes showing alcohol-induced differential expression between inbred strains C57BL/6J and DBA/2J. These genes were then correlated to alcohol-related QTLs to identify potential candidate genes. The experiment involved identifying genes expressed differentially in alcohol-induced and non-induced animals but the following list of candidate genes are only for alcohol-induced states. On mouse Chromosome 2, several candidate genes were identified for Actre2 at 48 cM,Actre3 at 63 cM, Actre4 at 65 cM, and Alcp1 at 37 cM. Candidate genes for Actre2 are Dlx1 (44 cM), Frzb (49.75 cM), D2Ertd391e, and Kai1 (49.6 cM). Candidate genes for Actre3 and Actre4 are Bdnf (62 cM) and Actc1 (64 cM), respectively. Candidate genes forAlcp1 are Pbx3 (22 cM), Hspa5 (22.5 cM), Rprm, Pkp4, and March7 (formerly Axot).
Marchf7	Chr2:60040086-60079555 (+)	J:98595	Microarray analysis was used to identify genes showing alcohol-induced differential expression between inbred strains C57BL/6J and DBA/2J. These genes were then correlated to alcohol-related QTLs to identify potential candidate genes. The experiment involved identifying genes expressed differentially in alcohol-induced and non-induced animals but the following list of candidate genes are only for alcohol-induced states. On mouse Chromosome 2, several candidate genes were identified for Actre2 at 48 cM,Actre3 at 63 cM, Actre4 at 65 cM, and Alcp1 at 37 cM. Candidate genes for Actre2 are Dlx1 (44 cM), Frzb (49.75 cM), D2Ertd391e, and Kai1 (49.6 cM). Candidate genes for Actre3 and Actre4 are Bdnf (62 cM) and Actc1 (64 cM), respectively. Candidate genes forAlcp1 are Pbx3 (22 cM), Hspa5 (22.5 cM), Rprm, Pkp4, and March7 (formerly Axot).
Pbx3	Chr2:34061469-34263154 (-)	J:98595	Microarray analysis was used to identify genes showing alcohol-induced differential expression between inbred strains C57BL/6J and DBA/2J. These genes were then correlated to alcohol-related QTLs to identify potential candidate genes. The experiment involved identifying genes expressed differentially in alcohol-induced and non-induced animals but the following list of candidate genes are only for alcohol-induced states. On mouse Chromosome 2, several candidate genes were identified for Actre2 at 48 cM,Actre3 at 63 cM, Actre4 at 65 cM, and Alcp1 at 37 cM. Candidate genes for Actre2 are Dlx1 (44 cM), Frzb (49.75 cM), D2Ertd391e, and Kai1 (49.6 cM). Candidate genes for Actre3 and Actre4 are Bdnf (62 cM) and Actc1 (64 cM), respectively. Candidate genes forAlcp1 are Pbx3 (22 cM), Hspa5 (22.5 cM), Rprm, Pkp4, and March7 (formerly Axot).
Pkp4	Chr2:58991194-59185552 (+)	J:98595	Microarray analysis was used to identify genes showing alcohol-induced differential expression between inbred strains C57BL/6J and DBA/2J. These genes were then correlated to alcohol-related QTLs to identify potential candidate genes. The experiment involved identifying genes expressed differentially in alcohol-induced and non-induced animals but the following list of candidate genes are only for alcohol-induced states. On mouse Chromosome 2, several candidate genes were identified for Actre2 at 48 cM,Actre3 at 63 cM, Actre4 at 65 cM, and Alcp1 at 37 cM. Candidate genes for Actre2 are Dlx1 (44 cM), Frzb (49.75 cM), D2Ertd391e, and Kai1 (49.6 cM). Candidate genes for Actre3 and Actre4 are Bdnf (62 cM) and Actc1 (64 cM), respectively. Candidate genes forAlcp1 are Pbx3 (22 cM), Hspa5 (22.5 cM), Rprm, Pkp4, and March7 (formerly Axot).
Rprm	Chr2:53974105-53975564 (-)	J:98595	Microarray analysis was used to identify genes showing alcohol-induced differential expression between inbred strains C57BL/6J and DBA/2J. These genes were then correlated to alcohol-related QTLs to identify potential candidate genes. The experiment involved identifying genes expressed differentially in alcohol-induced and non-induced animals but the following list of candidate genes are only for alcohol-induced states. On mouse Chromosome 2, several candidate genes were identified for Actre2 at 48 cM,Actre3 at 63 cM, Actre4 at 65 cM, and Alcp1 at 37 cM. Candidate genes for Actre2 are Dlx1 (44 cM), Frzb (49.75 cM), D2Ertd391e, and Kai1 (49.6 cM). Candidate genes for Actre3 and Actre4 are Bdnf (62 cM) and Actc1 (64 cM), respectively. Candidate genes forAlcp1 are Pbx3 (22 cM), Hspa5 (22.5 cM), Rprm, Pkp4, and March7 (formerly Axot).