Tg(APPV717F)109Ili
Transgene Detail

Summary

• Symbol: Tg(APPV717F)109Ili
• Name: transgene insertion 109, Ivan Lieberburg
• MGI ID: MGI:2151935
• Synonyms: APPInd, APP^V717F, hAPP+, hbeta-APP, PDAPP, PDAPP+, PDAPP-109, PD-APP transgenic, PDAPP-V717F, PDGF-hAPP(V717F), Tg(APP*Ind)109Ili
• Transgene: Tg(APPV717F)109Ili Location: unknown
• Alliance: Tg(APPV717F)109Ili page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(APPV717F)109Ili expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  APP (351)

  App	(MGI:88059)

  The gene encodes the V717F mutation.

• Mutation details: Overexpression of a human APP (hAPP) minigene encoding the APP717V to F mutation associated with familial Alzheimer's Disease. The construct contained APP introns 6 - 8, allowing alternative splicing of exons 7 and 8. The transgene utilizes a platelet-derived growth factor promoter (PDGF-b) and the three major splicing variants of hAPP mRNA were expressed in transgenic mice. As determined by RNAse protection, line 109 expressed ~ 18-fold more APP than previously described neuron-specific enolase (NSE)-promoter-driven APP transgenes. (J:23080, J:100980)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:23080 Games D, et al., Alzheimer-type neuropathology in transgenic mice overexpressing V717F beta-amyloid precursor protein [see comments]. Nature. 1995 Feb 9;373(6514):523-7
• All: 110 reference(s)