Ipo7 MGI Mouse Gene Detail - MGI:2152414

Symbol

Ipo7
Name

importin 7
Synonyms

A330055O14Rik, Imp7, RanBP7

Feature Type

protein coding gene
IDs

MGI:2152414
NCBI Gene: 233726
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr7:109617522-109655816 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 57.70 cM
Mapping Data

4 experiments

SNPs within 2kb

1036 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2152414	protein coding gene	Chr7:109617481-109655816 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0032852	protein coding gene	Chr7:113481645-113518409 (+)
A/J	MGP_AJ_G0032836	protein coding gene	Chr7:110666339-110703134 (+)
AKR/J	MGP_AKRJ_G0032767	protein coding gene	Chr7:113451498-113488227 (+)
BALB/cJ	MGP_BALBcJ_G0032840	protein coding gene	Chr7:110365002-110401584 (+)
C3H/HeJ	MGP_C3HHeJ_G0032550	protein coding gene	Chr7:113480970-113517629 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0033346	protein coding gene	Chr7:118182644-118222893 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030319	protein coding gene	Chr7:112240398-112280266 (+)
CAST/EiJ	MGP_CASTEiJ_G0031878	protein coding gene	Chr7:105017371-105058397 (+)
CBA/J	MGP_CBAJ_G0032523	protein coding gene	Chr7:122044794-122083794 (+)
DBA/2J	MGP_DBA2J_G0032675	protein coding gene	Chr7:108774671-108811719 (+)
FVB/NJ	MGP_FVBNJ_G0032628	protein coding gene	Chr7:108630117-108667457 (+)
LP/J	MGP_LPJ_G0032769	protein coding gene	Chr7:115011442-115049005 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032660	protein coding gene	Chr7:123706066-123746894 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033367	protein coding gene	Chr7:112459244-112498878 (+)
PWK/PhJ	MGP_PWKPhJ_G0031585	protein coding gene	Chr7:101587124-101630738 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0031433	protein coding gene	Chr7:99163209-99200199 (+)
WSB/EiJ	MGP_WSBEiJ_G0031991	protein coding gene	Chr7:113313184-113351349 (+)

Human Ortholog

IPO7, importin 7

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

IPO7, importin 7
Synonyms

Imp7, RANBP7
Links

HGNC:9852

NCBI Gene ID: 10527

neXtProt AC: NX_O95373

UniProt: O95373
Chr Location

11p15.4; chr11:9384652-9448127 (+) GRCh38

MGI Vertebrate Homology

Ipo7 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: IPO7
Gene Tree

Ipo7

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Phenotype Summary

18 phenotypes from 1 allele in 2 genetic backgrounds
1 images
20 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

67
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

63
Radiation induced

1
Genomic Mutations

2 involving Ipo7
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

82 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele show abnormal blastocyst morphology and complete embryonic lethality prior to organogenesis.

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All GO Annotations

26
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

18
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ipo7

ZFIN ipo7

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All Sequences

53
RefSeq

4
UniProt

2
CCDS

CCDS40085.1

Ensembl

ENSMUSG00000066232 (Evidence)
NCBI Gene

233726

			Length	Strain/Species	Flank
genomic	233726	NCBI Gene Model \| MGI Sequence Detail	38295	C57BL/6J	± kb
transcript	NM_181517	RefSeq \| MGI Sequence Detail	4722	C57BL/6
polypeptide	Q9EPL8	UniProt \| EBI \| MGI Sequence Detail	1038	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000009089 importin-7

(term hierarchy)
InterPro Domains

IPR011989 Armadillo-like helical

IPR016024 Armadillo-type fold

IPR013713 Exportin-2, central domain

IPR001494 Importin-beta, N-terminal domain
GlyGen

Q9EPL8 1 site, 1 O-linked glycan (1 site)

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All nucleic 20

Genomic 1

cDNA 19

Microarray probesets 3

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MGI:2442438

Summaries

All 56

Developmental Gene Expression 1

Gene Ontology 11

Phenotypes 20
Earliest

J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ipo7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr68477	Chr7:109617461-109617474 (+)	-54 bp
Tssr68478	Chr7:109617503-109617507 (+)	-17 bp
Tssr68479	Chr7:109617508-109617533 (+)	-1 bp
Tssr68481	Chr7:109628953-109628968 (+)	11,439 bp
Tssr68482	Chr7:109643327-109643332 (+)	25,808 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24