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Stk33 Gene Detail
Summary
  • Symbol
    Stk33
  • Name
    serine/threonine kinase 33
  • Synonyms
    4921505G21Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2152419
    NCBI Gene: 117229
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:108878430-109038288 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 57.21 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3569 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2152419
 protein coding gene Chr7:108878270-109038375 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032840
 protein coding gene Chr7:112686665-112858682 (-)
A/J MGP_AJ_G0032824
 protein coding gene Chr7:109917365-110079783 (-)
AKR/J MGP_AKRJ_G0032755
 protein coding gene Chr7:112649006-112825722 (-)
BALB/cJ MGP_BALBcJ_G0032828
 protein coding gene Chr7:109616358-109776182 (-)
C3H/HeJ MGP_C3HHeJ_G0032538
 protein coding gene Chr7:112707119-112870300 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033334
 protein coding gene Chr7:117388933-117552038 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030307
 protein coding gene Chr7:111497009-111650879 (-)
CAST/EiJ MGP_CASTEiJ_G0031866
 protein coding gene Chr7:104223910-104398761 (-)
CBA/J MGP_CBAJ_G0032511
 protein coding gene Chr7:121222049-121396034 (-)
DBA/2J MGP_DBA2J_G0032663
 protein coding gene Chr7:108029387-108191805 (-)
FVB/NJ MGP_FVBNJ_G0032616
 protein coding gene Chr7:107876633-108036854 (-)
LP/J MGP_LPJ_G0032757
 protein coding gene Chr7:114241785-114396373 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032648
 protein coding gene Chr7:122893720-123066658 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033355
 protein coding gene Chr7:111674338-111846705 (-)
PWK/PhJ MGP_PWKPhJ_G0031573
 protein coding gene Chr7:100829095-100987299 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031421
 protein coding gene Chr7:98362552-98532193 (-)
WSB/EiJ MGP_WSBEiJ_G0031979
 protein coding gene Chr7:112511754-112677999 (-)



Homology
more
  • Human Ortholog
    STK33, serine/threonine kinase 33
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    STK33, serine/threonine kinase 33
  • Synonyms
    SPGF93
  • Links
    NCBI Gene ID: 65975
    neXtProt AC: NX_Q9BYT3
    UniProt: Q9BYT3

  • Chr Location
    11p15.4; chr11:8334824-8594289 (-)  GRCh38
Human Diseases
more
  • Diseases
    3 with human STK33 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit male infertility associated with abnormal sperm flagellum morphology and asthenozoospermia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    788
  • Tissues
    48
  • cDNA Data
    18
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031027 Ensembl Gene Model | MGI Sequence Detail 159859 C57BL/6J ±  kb
    transcript ENSMUST00000121748 Ensembl | MGI Sequence Detail 2295 Not Applicable  
    polypeptide ENSMUSP00000112515 Ensembl | MGI Sequence Detail 491 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • EC
      2.7.11.1
    • InterPro Domains
      IPR017441 Protein kinase, ATP binding site
      IPR000719 Protein kinase domain
      IPR011009 Protein kinase-like domain superfamily
      IPR008271 Serine/threonine-protein kinase, active site
    Molecular
    Reagents
    less
    • All nucleic 21
      Genomic 2
      cDNA 18
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1921290, MGI:2142204
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 3
      Gene Ontology 11
      Phenotypes 21
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:352589 Ku AF, et al., Reversible male contraception by targeted inhibition of serine/threonine kinase 33. Science. 2024 May 24;384(6698):885-890
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    11/12/2024
    MGI 6.24     		The Jackson Laboratory