Ap5q QTL Detail

Summary

• Symbol
  Ap5q
• Name
  alcohol preference 5 QTL

• Feature Type
  QTL
• IDs
  MGI:2152432
  NCBI Gene: 117220
• Candidate Genes
  12 Genes

Location &
Maps

• Sequence Map
  Chr9:47053164-47053277 bp

  From MGI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 9, 25.70 cM (cM position of peak correlated region/marker)
• Mapping Data
  4 experiments

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  1 phenotype from 2 alleles in 1 genetic background
  1 phenotype reference
  

• All Mutations and Alleles
  2
• QTL
  2
• Find Mice (IMSR)
  0 strains or lines available

Sequences &
Gene Models

• NCBI Gene
  117220

References

• Summaries
  All 7

  Phenotypes 1
• Earliest
  J:49707 Tarantino LM, et al., Confirmation of quantitative trait loci for alcohol preference in mice. Alcohol Clin Exp Res. 1998 Aug;22(5):1099-105
• Latest
  J:153481 Weng J, et al., Ethanol-responsive genes (Crtam, Zbtb16, and Mobp) located in the alcohol-QTL region of chromosome 9 are associated with alcohol preference in mice. Alcohol Clin Exp Res. 2009 Aug;33(8):1409-16

Candidate Genes for Ap5q:

Gene	Genome Location (GRCm39)	Reference	QTL Note
Anln	Chr9:22243308-22300484 (-)	J:98595	Microarray analysis was used to identify genes showing alcohol-induced differential expression between inbred strains C57BL/6J and DBA/2J. These genes were then correlated to alcohol-related QTLs to identify potential candidate genes. The experiment involved identifying genes expressed differentially in alcohol-induced and non-induced animals but the following list of candidate genes are only for alcohol-induced states. On mouse Chromosome 9, several candidate genes were identified for Ap5q at 26 cM. These candidate genes are Edg5 (6 cM), Anln, Hspa8 (24 cM), Phldb1, Zbtb16 (23 cM), Rab7 (38.5 cM), Psma4, and Rplp1.
Arpp19	Chr9:74944896-74967595 (+)	J:98587	Microarray analysis was used to identify genes showing alcohol-induced differential expression between inbred strains C57BL/6J and DBA/2J. These genes were then correlated to 6 previously identified alcohol-related QTLs to identify potential candidate genes. Two different Affymetrix microarrays were used in the analysis. Brain expression data from parental strains and 56 (DBA/2J x C57BL/6J)F2 intercross animals were used for analysis. On mouse Chromosome 9, several candidate genes were identified for Ap5q at 26 cM. The highest priority candidate genes identified for Ap5q are Sorl1, Sc5d, Spg21 (40 cM, formerly D9Wsu18e), and Arpp19. Other candidate genes with a ranking of modest priority were identified but are not listed here.
Hspa8	Chr9:40712572-40716498 (+)	J:98595	Microarray analysis was used to identify genes showing alcohol-induced differential expression between inbred strains C57BL/6J and DBA/2J. These genes were then correlated to alcohol-related QTLs to identify potential candidate genes. The experiment involved identifying genes expressed differentially in alcohol-induced and non-induced animals but the following list of candidate genes are only for alcohol-induced states. On mouse Chromosome 9, several candidate genes were identified for Ap5q at 26 cM. These candidate genes are Edg5 (6 cM), Anln, Hspa8 (24 cM), Phldb1, Zbtb16 (23 cM), Rab7 (38.5 cM), Psma4, and Rplp1.
Phldb1	Chr9:44597601-44646495 (-)	J:98595	Microarray analysis was used to identify genes showing alcohol-induced differential expression between inbred strains C57BL/6J and DBA/2J. These genes were then correlated to alcohol-related QTLs to identify potential candidate genes. The experiment involved identifying genes expressed differentially in alcohol-induced and non-induced animals but the following list of candidate genes are only for alcohol-induced states. On mouse Chromosome 9, several candidate genes were identified for Ap5q at 26 cM. These candidate genes are Edg5 (6 cM), Anln, Hspa8 (24 cM), Phldb1, Zbtb16 (23 cM), Rab7 (38.5 cM), Psma4, and Rplp1.
Psma4	Chr9:54858074-54865314 (+)	J:98595	Microarray analysis was used to identify genes showing alcohol-induced differential expression between inbred strains C57BL/6J and DBA/2J. These genes were then correlated to alcohol-related QTLs to identify potential candidate genes. The experiment involved identifying genes expressed differentially in alcohol-induced and non-induced animals but the following list of candidate genes are only for alcohol-induced states. On mouse Chromosome 9, several candidate genes were identified for Ap5q at 26 cM. These candidate genes are Edg5 (6 cM), Anln, Hspa8 (24 cM), Phldb1, Zbtb16 (23 cM), Rab7 (38.5 cM), Psma4, and Rplp1.
Rab7	Chr6:87976088-88022252 (-)	J:98595	Microarray analysis was used to identify genes showing alcohol-induced differential expression between inbred strains C57BL/6J and DBA/2J. These genes were then correlated to alcohol-related QTLs to identify potential candidate genes. The experiment involved identifying genes expressed differentially in alcohol-induced and non-induced animals but the following list of candidate genes are only for alcohol-induced states. On mouse Chromosome 9, several candidate genes were identified for Ap5q at 26 cM. These candidate genes are Edg5 (6 cM), Anln, Hspa8 (24 cM), Phldb1, Zbtb16 (23 cM), Rab7 (38.5 cM), Psma4, and Rplp1.
Rplp1	Chr9:61820565-61821792 (-)	J:98595	Microarray analysis was used to identify genes showing alcohol-induced differential expression between inbred strains C57BL/6J and DBA/2J. These genes were then correlated to alcohol-related QTLs to identify potential candidate genes. The experiment involved identifying genes expressed differentially in alcohol-induced and non-induced animals but the following list of candidate genes are only for alcohol-induced states. On mouse Chromosome 9, several candidate genes were identified for Ap5q at 26 cM. These candidate genes are Edg5 (6 cM), Anln, Hspa8 (24 cM), Phldb1, Zbtb16 (23 cM), Rab7 (38.5 cM), Psma4, and Rplp1.
S1pr2	Chr9:20877248-20888089 (-)	J:98595	Microarray analysis was used to identify genes showing alcohol-induced differential expression between inbred strains C57BL/6J and DBA/2J. These genes were then correlated to alcohol-related QTLs to identify potential candidate genes. The experiment involved identifying genes expressed differentially in alcohol-induced and non-induced animals but the following list of candidate genes are only for alcohol-induced states. On mouse Chromosome 9, several candidate genes were identified for Ap5q at 26 cM. These candidate genes are Edg5 (6 cM), Anln, Hspa8 (24 cM), Phldb1, Zbtb16 (23 cM), Rab7 (38.5 cM), Psma4, and Rplp1.
Sc5d	Chr9:42162891-42175552 (-)	J:98587	Microarray analysis was used to identify genes showing alcohol-induced differential expression between inbred strains C57BL/6J and DBA/2J. These genes were then correlated to 6 previously identified alcohol-related QTLs to identify potential candidate genes. Two different Affymetrix microarrays were used in the analysis. Brain expression data from parental strains and 56 (DBA/2J x C57BL/6J)F2 intercross animals were used for analysis. On mouse Chromosome 9, several candidate genes were identified for Ap5q at 26 cM. The highest priority candidate genes identified for Ap5q are Sorl1, Sc5d, Spg21 (40 cM, formerly D9Wsu18e), and Arpp19. Other candidate genes with a ranking of modest priority were identified but are not listed here.
Sorl1	Chr9:41876016-42035593 (-)	J:98587	Microarray analysis was used to identify genes showing alcohol-induced differential expression between inbred strains C57BL/6J and DBA/2J. These genes were then correlated to 6 previously identified alcohol-related QTLs to identify potential candidate genes. Two different Affymetrix microarrays were used in the analysis. Brain expression data from parental strains and 56 (DBA/2J x C57BL/6J)F2 intercross animals were used for analysis. On mouse Chromosome 9, several candidate genes were identified for Ap5q at 26 cM. The highest priority candidate genes identified for Ap5q are Sorl1, Sc5d, Spg21 (40 cM, formerly D9Wsu18e), and Arpp19. Other candidate genes with a ranking of modest priority were identified but are not listed here.
Spg21	Chr9:65368229-65395752 (+)	J:98587	Microarray analysis was used to identify genes showing alcohol-induced differential expression between inbred strains C57BL/6J and DBA/2J. These genes were then correlated to 6 previously identified alcohol-related QTLs to identify potential candidate genes. Two different Affymetrix microarrays were used in the analysis. Brain expression data from parental strains and 56 (DBA/2J x C57BL/6J)F2 intercross animals were used for analysis. On mouse Chromosome 9, several candidate genes were identified for Ap5q at 26 cM. The highest priority candidate genes identified for Ap5q are Sorl1, Sc5d, Spg21 (40 cM, formerly D9Wsu18e), and Arpp19. Other candidate genes with a ranking of modest priority were identified but are not listed here.
Zbtb16	Chr9:48565597-48747522 (-)	J:98595	Microarray analysis was used to identify genes showing alcohol-induced differential expression between inbred strains C57BL/6J and DBA/2J. These genes were then correlated to alcohol-related QTLs to identify potential candidate genes. The experiment involved identifying genes expressed differentially in alcohol-induced and non-induced animals but the following list of candidate genes are only for alcohol-induced states. On mouse Chromosome 9, several candidate genes were identified for Ap5q at 26 cM. These candidate genes are Edg5 (6 cM), Anln, Hspa8 (24 cM), Phldb1, Zbtb16 (23 cM), Rab7 (38.5 cM), Psma4, and Rplp1.