Apoca Gene Detail

Summary

• Symbol
  Apoca
• Name
  anterior polar cataract
• Synonyms
  Apoc

• Feature Type
  heritable phenotypic marker
• IDs
  MGI:2152879
  NCBI Gene: 117587
• Alliance
  gene page

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome Unknown

Human Diseases

• Diseases
  1 with Apoca mouse models

Human Disease

Mouse Models

cataract

IDs

cataract      

DOID:83
ICD10CM:H26
ICD9CM:366.8
OMIM:601371
OMIM:PS116200
UMLS_CUI:C0029531

View 1 model

Mouse Models

Human Disease Modeled: cataract

Allelic Composition	Genetic Background	Reference	Phenotypes
Apoca/Apoca+	involves: 101 * C3H	J:9528	View

Click on a disease name to see all genes associated with that disease.

• Mutations/Alleles
  1 with disease annotations

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  9 phenotypes from 1 allele in 1 genetic background
  2 phenotype references
  

• All Mutations and Alleles
  1
• Radiation induced
  1
• Find Mice (IMSR)
  0 strains or lines available

Homozygous mutation of this gene results in embryonic lethality. Heterozygous mutant animals display cataracts and reduced litter size. Non-Mendelian segregation of this allele suggests semilethality.

Sequences &
Gene Models

• NCBI Gene
  117587

References

• Summaries
  All 3

  Diseases 1

  Phenotypes 2
• Earliest
  J:6686 Kratochvilova J, Dominant cataract mutations detected in offspring of gamma-irradiated male mice. J Hered. 1981 Sep-Oct;72(5):302-7
• Latest
  J:9528 Kratochvilova J, et al., Phenotypic characterization and genetic analysis of twenty dominant cataract mutations detected in offspring of irradiated male mice. Genet Res. 1988 Oct;52(2):125-34