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Trim37 Gene Detail
Summary
  • Symbol
    Trim37
  • Name
    tripartite motif-containing 37
  • Synonyms
    1110032A10Rik, 2810004E07Rik, MUL, TEF3
  • Feature Type
    protein coding gene
  • IDs
    MGI:2153072
    NCBI Gene: 68729
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:87017903-87111509 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 51.93 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    250 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2153072
 protein coding gene Chr11:87017675-87141700 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018901
 protein coding gene Chr11:88704700-88801628 (+)
A/J MGP_AJ_G0018868
 protein coding gene Chr11:85297772-85392353 (+)
AKR/J MGP_AKRJ_G0018838
 protein coding gene Chr11:87842427-87949805 (+)
BALB/cJ MGP_BALBcJ_G0018841
 protein coding gene Chr11:85682656-85784932 (+)
C3H/HeJ MGP_C3HHeJ_G0018655
 protein coding gene Chr11:87868225-87965267 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019293
 protein coding gene Chr11:91377089-91476052 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016926
 protein coding gene Chr11:82326266-82417970 (+)
CAST/EiJ MGP_CASTEiJ_G0018210
 protein coding gene Chr11:88579384-88705455 (+)
CBA/J MGP_CBAJ_G0018626
 protein coding gene Chr11:95221447-95329597 (+)
DBA/2J MGP_DBA2J_G0018734
 protein coding gene Chr11:84857828-84950562 (+)
FVB/NJ MGP_FVBNJ_G0018723
 protein coding gene Chr11:84364020-84457930 (+)
LP/J MGP_LPJ_G0018804
 protein coding gene Chr11:89208167-89309355 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018750
 protein coding gene Chr11:95308976-95409001 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019333
 protein coding gene Chr11:88086352-88183291 (+)
PWK/PhJ MGP_PWKPhJ_G0017980
 protein coding gene Chr11:85671843-85798903 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017772
 protein coding gene Chr11:87653957-87761102 (+)
WSB/EiJ MGP_WSBEiJ_G0018261
 protein coding gene Chr11:87964064-88061841 (+)



Homology
more
  • Human Ortholog
    TRIM37, tripartite motif containing 37
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRIM37, tripartite motif containing 37
  • Synonyms
    MUL, POB1, TEF3
  • Links
    NCBI Gene ID: 4591
    neXtProt AC: NX_O94972
    UniProt: O94972

  • Chr Location
    17q22; chr17:58967201-59106921 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Trim37 mouse models; 1 with human TRIM37 associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    43 phenotypes from 1 allele in 1 genetic background
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are infertile due to gonadal degeneration and exhibit late-onset weight loss, smaller skull size, non-compaction cardiomyopathy, hepatomegaly, fatty liver, altered glucose metabolism, splenomegaly, and increased tumor incidence.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    57
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    793
  • Tissues
    48
  • cDNA Data
    201
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000018548 Ensembl Gene Model | MGI Sequence Detail 93607 C57BL/6J ±  kb
    transcript ENSMUST00000041282 Ensembl | MGI Sequence Detail 5632 Not Applicable  
    polypeptide ENSMUSP00000049057 Ensembl | MGI Sequence Detail 961 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 202
      cDNA 202

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGI:1915979, MGI:1919603, MGI:2144298, MGI:2144435
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 9
      Phenotypes 14
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:347049 Liu J, et al., Increased alveolar epithelial TRAF6 via autophagy-dependent TRIM37 degradation mediates particulate matter-induced lung metastasis. Autophagy. 2022 May;18(5):971-989
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory