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Trrap Gene Detail
Summary
  • Symbol
    Trrap
  • Name
    transformation/transcription domain-associated protein
  • Synonyms
    transactivation/transformation-domain associated protein
  • Feature Type
    protein coding gene
  • IDs
    MGI:2153272
    NCBI Gene: 100683
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:144704547-144796588 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 84.77 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    2540 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2153272
 protein coding gene Chr5:144704542-144796588 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030352
 protein coding gene Chr5:150161683-150254958 (+)
A/J MGP_AJ_G0030321
 protein coding gene Chr5:143690565-143784728 (+)
AKR/J MGP_AKRJ_G0030253
 protein coding gene Chr5:148181699-148275660 (+)
BALB/cJ MGP_BALBcJ_G0030338
 protein coding gene Chr5:144967680-145059988 (+)
C3H/HeJ MGP_C3HHeJ_G0030049
 protein coding gene Chr5:148998396-149090175 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030783
 protein coding gene Chr5:155631771-155727690 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028002
 protein coding gene Chr5:137460420-137554404 (+)
CAST/EiJ MGP_CASTEiJ_G0029454
 protein coding gene Chr5:148562928-148657739 (+)
CBA/J MGP_CBAJ_G0030019
 protein coding gene Chr5:162042780-162136731 (+)
DBA/2J MGP_DBA2J_G0030169
 protein coding gene Chr5:143433016-143525667 (+)
FVB/NJ MGP_FVBNJ_G0030124
 protein coding gene Chr5:142652496-142745570 (+)
LP/J MGP_LPJ_G0030255
 protein coding gene Chr5:150740612-150836343 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030155
 protein coding gene Chr5:164376021-164469745 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030823
 protein coding gene Chr5:148085810-148178883 (+)
PWK/PhJ MGP_PWKPhJ_G0029169
 protein coding gene Chr5:142568925-142663129 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029005
 protein coding gene Chr5:145816032-145917444 (+)
WSB/EiJ MGP_WSBEiJ_G0029527
 protein coding gene Chr5:148874973-148966788 (+)



Homology
more
  • Human Ortholog
    TRRAP, transformation/transcription domain associated protein
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRRAP, transformation/transcription domain associated protein
  • Synonyms
    DEDDFA, DFNA75, PAF350/400, PAF400, STAF40, Tra1, TR-AP
  • Links
    NCBI Gene ID: 8295
    neXtProt AC: NX_Q9Y4A5
    UniProt: Q9Y4A5

  • Chr Location
    7q22.1; chr7:98877933-99050831 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human TRRAP associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 3 alleles in 2 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous embryos die prior to E3.5 and exhibit embryonic and extraembryonic tissue disorganization. Mitotic abnormalities were also noted in homozygous cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    36
  • GO References
    19
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    784
  • Tissues
    16
  • cDNA Data
    195
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 100683 NCBI Gene Model | MGI Sequence Detail 92042 C57BL/6J ±  kb
    transcript NM_001081362 RefSeq | MGI Sequence Detail 12479 C57BL/6  
    polypeptide Q80YV3 UniProt | EBI | MGI Sequence Detail 2565 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      9 Sequences
    • Protein Ontology
      PR:000016706 transformation/transcription domain-associated protein
      (term hierarchy)
    • InterPro Domains
      IPR011989 Armadillo-like helical
      IPR016024 Armadillo-type fold
      IPR050517 DNA Damage Response and Repair Kinase
      IPR003152 FATC domain
      IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain
      IPR036940 Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily
      IPR014009 PIK-related kinase
      IPR003151 PIK-related kinase, FAT
      IPR011009 Protein kinase-like domain superfamily
      IPR046807 Tra1, HEAT repeat central region
      IPR046805 Tra1, HEAT repeat ring region
    • GlyGen
      Q80YV3 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 196
      cDNA 196

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2140918
    References
    more
    • Summaries
      All 60
      Developmental Gene Expression 5
      Gene Ontology 19
      Phenotypes 17
    • Earliest
      J:320277 Ogryzko VV, et al., Histone-like TAFs within the PCAF histone acetylase complex. Cell. 1998 Jul 10;94(1):35-44
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory