Rnf34 MGI Mouse Gene Detail - MGI:2153340

Symbol

Rnf34
Name

ring finger protein 34
Synonyms

MGC:7670, phafin 1

Feature Type

protein coding gene
IDs

MGI:2153340
NCBI Gene: 80751
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr5:122988270-123007008 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 62.62 cM
Mapping Data

2 experiments

SNPs within 2kb

491 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2153340	protein coding gene	Chr5:122988111-123009354 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0030059	protein coding gene	Chr5:126523382-126547458 (+)
A/J	MGP_AJ_G0030024	protein coding gene	Chr5:121269954-121291668 (+)
AKR/J	MGP_AKRJ_G0029960	protein coding gene	Chr5:125176945-125201262 (+)
BALB/cJ	MGP_BALBcJ_G0030035	protein coding gene	Chr5:122616987-122639039 (+)
C3H/HeJ	MGP_C3HHeJ_G0029752	protein coding gene	Chr5:125802493-125823256 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0030488	protein coding gene	Chr5:131390411-131415213 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027714	protein coding gene	Chr5:115868824-115892743 (+)
CAST/EiJ	MGP_CASTEiJ_G0029161	protein coding gene	Chr5:124894619-124917130 (+)
CBA/J	MGP_CBAJ_G0029722	protein coding gene	Chr5:136539182-136564290 (+)
DBA/2J	MGP_DBA2J_G0029872	protein coding gene	Chr5:121327374-121350049 (+)
FVB/NJ	MGP_FVBNJ_G0029828	protein coding gene	Chr5:120325165-120346473 (+)
LP/J	MGP_LPJ_G0029961	protein coding gene	Chr5:127054541-127079780 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029859	protein coding gene	Chr5:140230450-140254274 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030529	protein coding gene	Chr5:124774871-124800927 (+)
PWK/PhJ	MGP_PWKPhJ_G0028875	protein coding gene	Chr5:120112421-120132684 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028712	protein coding gene	Chr5:122481182-122503076 (+)
WSB/EiJ	MGP_WSBEiJ_G0029236	protein coding gene	Chr5:125444318-125467772 (+)

Human Ortholog

RNF34, ring finger protein 34

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RNF34, ring finger protein 34
Synonyms

CARP-1, CARP1, hRFI, RFI, RIF, RIFF
Links

HGNC:17297

NCBI Gene ID: 80196

neXtProt AC: NX_Q969K3

UniProt: Q969K3
Chr Location

12q24.31; chr12:121400083-121430623 (+) GRCh38

MGI Vertebrate Homology

Rnf34 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: RNF34
Gene Tree

Rnf34

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Phenotype Summary

12 phenotype references

All Mutations and Alleles

16
Chemically induced (other)

1
Gene trapped

12
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Rnf34
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

25 strains or lines available

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All GO Annotations

46
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

743
Tissues

30
cDNA Data

18
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rnf34

ZFIN rnf34a

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All Sequences

53
RefSeq

6
UniProt

2
CCDS

CCDS19656.1

Ensembl

ENSMUSG00000029474 (Evidence)
NCBI Gene

80751

			Length	Strain/Species	Flank
genomic	80751	NCBI Gene Model \| MGI Sequence Detail	18739	C57BL/6J	± kb
transcript	NM_001417908	RefSeq \| MGI Sequence Detail	2059	C57BL/6
polypeptide	Q99KR6	UniProt \| EBI \| MGI Sequence Detail	376	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000014131 E3 ubiquitin-protein ligase RNF34

(term hierarchy)
EC

2.3.2.27
InterPro Domains

IPR049320 E3 ubiquitin-protein ligase CARP1/2, FYVE/PHD zinc finger

IPR049323 E3 ubiquitin-protein ligase CARP1, FYVE/PHD zinc finger

IPR051728 RING-FYVE domain-containing E3 ubiquitin-protein ligase

IPR036361 SAP domain superfamily

IPR011011 Zinc finger, FYVE/PHD-type

IPR013083 Zinc finger, RING/FYVE/PHD-type

IPR001841 Zinc finger, RING-type
GlyGen

Q99KR6 3 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (2 sites)

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All nucleic 18

cDNA 18

Microarray probesets 4

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MGI:2136842, MGI:2141146, MGI:2141205, MGI:2141347

Summaries

All 45

Developmental Gene Expression 3

Gene Ontology 8

Phenotypes 12
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:322258 Fang S, et al., RNF34 ablation promotes cerebrovascular remodeling and hypertension by increasing NADPH-derived ROS generation. Neurobiol Dis. 2021 Aug;156:105396

TSS for Rnf34:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr48722	Chr5:122988198-122988205 (+)	-68 bp
Tssr48723	Chr5:122988217-122988228 (+)	-47 bp
Tssr48724	Chr5:122988230-122988241 (+)	-34 bp
Tssr48725	Chr5:122988249-122988261 (+)	-15 bp
Tssr48726	Chr5:122988262-122988277 (+)	0 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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