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Dmbx1 Gene Detail
Summary
  • Symbol
    Dmbx1
  • Name
    diencephalon/mesencephalon homeobox 1
  • Synonyms
    Atx, Cdmx, Dmbx1, Mbx, Otx3
  • Feature Type
    protein coding gene
  • IDs
    MGI:2153518
    NCBI Gene: 140477
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:115772316-115797123 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 53.07 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    623 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2153518
 protein coding gene Chr4:115772316-115797794 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028613
 protein coding gene Chr4:116760113-116784774 (-)
A/J MGP_AJ_G0028574
 protein coding gene Chr4:112305159-112329459 (-)
AKR/J MGP_AKRJ_G0028523
 protein coding gene Chr4:114711714-114736375 (-)
BALB/cJ MGP_BALBcJ_G0028595
 protein coding gene Chr4:112933530-112958045 (-)
C3H/HeJ MGP_C3HHeJ_G0028309
 protein coding gene Chr4:116291769-116316180 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029036
 protein coding gene Chr4:121285673-121310527 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026320
 protein coding gene Chr4:106351488-106376386 (-)
CAST/EiJ MGP_CASTEiJ_G0027743
 protein coding gene Chr4:113499395-113526816 (-)
CBA/J MGP_CBAJ_G0028276
 protein coding gene Chr4:124577220-124601486 (-)
DBA/2J MGP_DBA2J_G0028424
 protein coding gene Chr4:112954175-112978572 (-)
FVB/NJ MGP_FVBNJ_G0028392
 protein coding gene Chr4:111440820-111465557 (-)
LP/J MGP_LPJ_G0028526
 protein coding gene Chr4:116976646-117001299 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028419
 protein coding gene Chr4:129597544-129623123 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029073
 protein coding gene Chr4:115869690-115894734 (-)
PWK/PhJ MGP_PWKPhJ_G0027469
 protein coding gene Chr4:109713371-109738917 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027292
 protein coding gene Chr4:112114745-112139794 (-)
WSB/EiJ MGP_WSBEiJ_G0027822
 protein coding gene Chr4:115736209-115763700 (-)



Homology
more
  • Human Ortholog
    DMBX1, diencephalon/mesencephalon homeobox 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DMBX1, diencephalon/mesencephalon homeobox 1
  • Synonyms
    Atx, MBX, OTX3, PAXB
  • Links
    NCBI Gene ID: 127343
    neXtProt AC: NX_Q8NFW5
    UniProt: Q8NFW5

  • Chr Location
    1p33; chr1:46489836-46516216 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 6 alleles in 4 genetic backgrounds
    3 phenotypes from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for one null allele display partial postnatal lethality, impaired suckling and postnatal growth, and reduced female fertility. When raised in isolation, mice homozygous for another null allele exhibit decreased body weight, decreased food consumption, and small adipocytes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1223
  • Tissues
    318
  • cDNA Data
    15
  • Literature Summary
    32
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028707 Ensembl Gene Model | MGI Sequence Detail 24808 C57BL/6J ±  kb
    transcript ENSMUST00000084338 Ensembl | MGI Sequence Detail 4031 Not Applicable  
    polypeptide ENSMUSP00000081366 Ensembl | MGI Sequence Detail 381 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 31
      cDNA 15
      Primer pair 6
      Other 10

      Microarray probesets 3
    References
    more
    • Summaries
      All 64
      Developmental Gene Expression 32
      Gene Ontology 6
      Phenotypes 14
    • Earliest
      J:72725 Martinez-Barbera JP, et al., Regionalisation of anterior neuroectoderm and its competence in responding to forebrain and midbrain inducing activities depend on mutual antagonism between OTX2 and GBX2. Development. 2001 Dec;128(23):4789-800
    • Latest
      J:340418 Amadei G, et al., Embryo model completes gastrulation to neurulation and organogenesis. Nature. 2022 Oct;610(7930):143-153
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory