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Ppp1r3a Gene Detail
Summary
  • Symbol
    Ppp1r3a
  • Name
    protein phosphatase 1, regulatory subunit 3A
  • Synonyms
    GM, RGL
  • Feature Type
    protein coding gene
  • IDs
    MGI:2153588
    NCBI Gene: 140491
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:14713976-14755273 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 6.31 cM, cytoband A2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1171 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2153588
 protein coding gene Chr6:14713821-14755273 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030463
 protein coding gene Chr6:11839806-11886110 (-)
A/J MGP_AJ_G0030436
 protein coding gene Chr6:11362851-11405463 (-)
AKR/J MGP_AKRJ_G0030363
 protein coding gene Chr6:11797517-11843207 (-)
BALB/cJ MGP_BALBcJ_G0030445
 protein coding gene Chr6:11412610-11455784 (-)
C3H/HeJ MGP_C3HHeJ_G0030159
 protein coding gene Chr6:11672356-11715284 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030900
 protein coding gene Chr6:12270836-12313529 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028111
 protein coding gene Chr6:10505287-10545359 (-)
CAST/EiJ MGP_CASTEiJ_G0029561
 protein coding gene Chr6:11528911-11572342 (-)
CBA/J MGP_CBAJ_G0030137
 protein coding gene Chr6:12630351-12677272 (-)
DBA/2J MGP_DBA2J_G0030281
 protein coding gene Chr6:11305116-11346914 (-)
FVB/NJ MGP_FVBNJ_G0030235
 protein coding gene Chr6:11192526-11233888 (-)
LP/J MGP_LPJ_G0030368
 protein coding gene Chr6:11923131-11965871 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030271
 protein coding gene Chr6:13469447-13546101 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030930
 protein coding gene Chr6:11662972-11704982 (-)
PWK/PhJ MGP_PWKPhJ_G0029275
 protein coding gene Chr6:10991619-11033032 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029111
 protein coding gene Chr6:11525775-11567349 (-)
WSB/EiJ MGP_WSBEiJ_G0029637
 protein coding gene Chr6:11594481-11640226 (-)



Homology
more
  • Human Ortholog
    PPP1R3A, protein phosphatase 1 regulatory subunit 3A
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PPP1R3A, protein phosphatase 1 regulatory subunit 3A
  • Synonyms
    GM, PP1G, PPP1R3
  • Links
    NCBI Gene ID: 5506
    neXtProt AC: NX_Q16821
    UniProt: Q16821

  • Chr Location
    7q31.1; chr7:113876777-114075920 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Ppp1r3a mouse models; 2 with human PPP1R3A associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice have reduced levels of skeletal muscle glycogen. Whereas one model was normoglycemic and grossly normal, another on a similar genetic background was glucose intolerant, insulin resistant, and gained weight to the point of obesity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    708
  • Tissues
    1
  • cDNA Data
    8
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000042717 Ensembl Gene Model | MGI Sequence Detail 41298 C57BL/6J ±  kb
    transcript ENSMUST00000045096 Ensembl | MGI Sequence Detail 6965 Not Applicable  
    polypeptide ENSMUSP00000049054 Ensembl | MGI Sequence Detail 1089 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000013124 protein phosphatase 1 regulatory subunit 3A
      (term hierarchy)
    • InterPro Domains
      IPR005036 CBM21 (carbohydrate binding type-21) domain
      IPR038175 CBM21 domain superfamily
      IPR050782 Protein phosphatase 1 regulatory subunit 3
    • GlyGen
      Q99MR9 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 8
      Primer pair 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 3
      Phenotypes 14
    • Earliest
      J:68370 Suzuki Y, et al., Insulin control of glycogen metabolism in knockout mice lacking the muscle-specific protein phosphatase PP1G/RGL. Mol Cell Biol. 2001 Apr;21(8):2683-94
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory