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Map4k3 Gene Detail
Summary
  • Symbol
    Map4k3
  • Name
    mitogen-activated protein kinase kinase kinase kinase 3
  • Synonyms
    4833416M07Rik, 9530052P13Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2154405
    NCBI Gene: 225028
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:80887941-81035914 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 50.97 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    4416 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2154405
 protein coding gene Chr17:80887941-81039118 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024066
 protein coding gene Chr17:83522016-83674374 (-)
A/J MGP_AJ_G0024023
 protein coding gene Chr17:80974382-81120649 (-)
AKR/J MGP_AKRJ_G0023992
 protein coding gene Chr17:82230513-82388905 (-)
BALB/cJ MGP_BALBcJ_G0024025
 protein coding gene Chr17:80826571-80975432 (-)
C3H/HeJ MGP_C3HHeJ_G0023789
 protein coding gene Chr17:83089532-83239205 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024469
 protein coding gene Chr17:86556353-86705000 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021910
 protein coding gene Chr17:76299340-76455526 (-)
CAST/EiJ MGP_CASTEiJ_G0023269
 protein coding gene Chr17:83779696-83933246 (-)
CBA/J MGP_CBAJ_G0023763
 protein coding gene Chr17:90177400-90340062 (-)
DBA/2J MGP_DBA2J_G0023892
 protein coding gene Chr17:79447757-79595349 (-)
FVB/NJ MGP_FVBNJ_G0023858
 protein coding gene Chr17:78947058-79094578 (-)
LP/J MGP_LPJ_G0023975
 protein coding gene Chr17:84364717-84516283 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023886
 protein coding gene Chr17:90210105-90371691 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024514
 protein coding gene Chr17:82708918-82869928 (-)
PWK/PhJ MGP_PWKPhJ_G0023015
 protein coding gene Chr17:79005632-79158633 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022826
 protein coding gene Chr17:79501221-79657575 (-)
WSB/EiJ MGP_WSBEiJ_G0023336
 protein coding gene Chr17:83538714-83696434 (-)



Homology
more
  • Human Ortholog
    MAP4K3, mitogen-activated protein kinase kinase kinase kinase 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MAP4K3, mitogen-activated protein kinase kinase kinase kinase 3
  • Synonyms
    GLK, MAPKKKK3, MEKKK 3, MEKKK3, RAB8IPL1
  • Links
    NCBI Gene ID: 8491
    neXtProt AC: NX_Q8IVH8
    UniProt: Q8IVH8

  • Chr Location
    2p22.1; chr2:39249266-39437301 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit decreased susceptibility to experimental autoimmune encephalomyelitis, decreased stimulated immunoglobin production, decreased stimulated T cell proliferation, and abnormal Th1, Th2, and Th17 differentiation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    41
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    824
  • Tissues
    109
  • cDNA Data
    15
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024242 Ensembl Gene Model | MGI Sequence Detail 147974 C57BL/6J ±  kb
    transcript ENSMUST00000112389 Ensembl | MGI Sequence Detail 4231 Not Applicable  
    polypeptide ENSMUSP00000108008 Ensembl | MGI Sequence Detail 896 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 15
      Primer pair 1
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1926112
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 2
      Gene Ontology 9
      Phenotypes 12
    • Earliest
      J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
    • Latest
      J:346793 Chi JN, et al., MAP4K3/GLK inhibits Treg differentiation by direct phosphorylating IKKbeta and inducing IKKbeta-mediated FoxO1 nuclear export and Foxp3 downregulation. Theranostics. 2022;12(13):5744-5760
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory