Ap7q QTL Detail

Summary

• Symbol
  Ap7q
• Name
  alcohol preference 7 QTL

• Feature Type
  QTL
• IDs
  MGI:2155164
  NCBI Gene: 259280
• Candidate Genes
  3 Genes

Location &
Maps

• Sequence Map
  Chr7:48714845-48715077 bp

  From MGI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 7, 31.19 cM (cM position of peak correlated region/marker)
• Mapping Data
  2 experiments

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  1 phenotype from 2 alleles in 1 genetic background
  1 phenotype reference
  

• All Mutations and Alleles
  2
• QTL
  2
• Find Mice (IMSR)
  5 strains or lines available

Sequences &
Gene Models

• NCBI Gene
  259280

References

• Summaries
  All 3

  Phenotypes 1
• Earliest
  J:78215 Bachmanov AA, et al., Voluntary ethanol consumption by mice: genome-wide analysis of quantitative trait loci and their interactions in a C57BL/6ByJ x 129P3/J F2 intercross. Genome Res. 2002 Aug;12(8):1257-68
• Latest
  J:98595 Kerns RT, et al., Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. J Neurosci. 2005 Mar 2;25(9):2255-66

Candidate Genes for Ap7q:

Gene	Genome Location (GRCm39)	Reference	QTL Note
Dbp	Chr7:45354658-45359579 (+)	J:98595	Microarray analysis was used to identify genes showing alcohol-induced differential expression between inbred strains C57BL/6J and DBA/2J. These genes were then correlated to alcohol-related QTLs to identify potential candidate genes. The experiment involved identifying genes expressed differentially in alcohol-induced and non-induced animals but the following list of candidate genes are only for alcohol-induced states. On mouse Chromosome 7 candidate genes identified for Ap7q at 25 cM are Fxyd7, Dbp (23 cM), and Kcnc1 (23.5 cM).
Fxyd7	Chr7:30741940-30750879 (-)	J:98595	Microarray analysis was used to identify genes showing alcohol-induced differential expression between inbred strains C57BL/6J and DBA/2J. These genes were then correlated to alcohol-related QTLs to identify potential candidate genes. The experiment involved identifying genes expressed differentially in alcohol-induced and non-induced animals but the following list of candidate genes are only for alcohol-induced states. On mouse Chromosome 7 candidate genes identified for Ap7q at 25 cM are Fxyd7, Dbp (23 cM), and Kcnc1 (23.5 cM).
Kcnc1	Chr7:46045921-46088128 (+)	J:98595	Microarray analysis was used to identify genes showing alcohol-induced differential expression between inbred strains C57BL/6J and DBA/2J. These genes were then correlated to alcohol-related QTLs to identify potential candidate genes. The experiment involved identifying genes expressed differentially in alcohol-induced and non-induced animals but the following list of candidate genes are only for alcohol-induced states. On mouse Chromosome 7 candidate genes identified for Ap7q at 25 cM are Fxyd7, Dbp (23 cM), and Kcnc1 (23.5 cM).