Gpr6 MGI Mouse Gene Detail - MGI:2155249 - G protein-coupled receptor 6

Symbol

Gpr6
Name

G protein-coupled receptor 6

Feature Type

protein coding gene
IDs

MGI:2155249
NCBI Gene: 140741
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr10:40945973-40948281 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 22.08 cM
Mapping Data

3 experiments

SNPs within 2kb

115 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2155249	protein coding gene	Chr10:40945973-40948286 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0017169	protein coding gene	Chr10:39708301-39710598 (-)
A/J	MGP_AJ_G0017146	protein coding gene	Chr10:38601628-38603924 (-)
AKR/J	MGP_AKRJ_G0017106	protein coding gene	Chr10:39166179-39168475 (-)
BALB/cJ	MGP_BALBcJ_G0017108	protein coding gene	Chr10:38672790-38675086 (-)
C3H/HeJ	MGP_C3HHeJ_G0016929	protein coding gene	Chr10:39482312-39484608 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0017567	protein coding gene	Chr10:40918943-40921239 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015263	protein coding gene	Chr10:36552512-36554811 (-)
CAST/EiJ	MGP_CASTEiJ_G0016508	protein coding gene	Chr10:39684782-39687079 (-)
CBA/J	MGP_CBAJ_G0016903	protein coding gene	Chr10:42781249-42783545 (-)
DBA/2J	MGP_DBA2J_G0017008	protein coding gene	Chr10:38105762-38108058 (-)
FVB/NJ	MGP_FVBNJ_G0017003	protein coding gene	Chr10:37596061-37598357 (-)
LP/J	MGP_LPJ_G0017085	protein coding gene	Chr10:39675289-39677586 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017033	protein coding gene	Chr10:43600122-43602418 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017604	protein coding gene	Chr10:39135040-39137336 (-)
PWK/PhJ	MGP_PWKPhJ_G0016288	protein coding gene	Chr10:37996191-37998488 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0016072	protein coding gene	Chr10:38968785-38971083 (-)
WSB/EiJ	MGP_WSBEiJ_G0016571	protein coding gene	Chr10:39476170-39478466 (-)

Human Ortholog

GPR6, G protein-coupled receptor 6

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GPR6, G protein-coupled receptor 6
Links

HGNC:4515

NCBI Gene ID: 2830

neXtProt AC: NX_P46095

UniProt: P46095
Chr Location

6q21; chr6:109978256-109980720 (+) GRCh38

MGI Vertebrate Homology

Gpr6 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: GPR6
Gene Tree

Gpr6

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Phenotype Summary

3 phenotypes from 1 allele in 2 genetic backgrounds
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (other)

1
Endonuclease-mediated

2
Radiation induced

1
Targeted

7
Genomic Mutations

2 involving Gpr6
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

33 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutation of this gene does not appear to result in a phenotype.

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All GO Annotations

9
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

906
Tissues

129
cDNA Data

6
Literature Summary

11

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

ZFIN gpr6

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All Sequences

33
RefSeq

3
UniProt

2
CCDS

CCDS23802.1

Ensembl

ENSMUSG00000046922 (Evidence)
NCBI Gene

140741

			Length	Strain/Species	Flank
genomic	ENSMUSG00000046922	Ensembl Gene Model \| MGI Sequence Detail	2309	C57BL/6J	± kb
transcript	ENSMUST00000061796	Ensembl \| MGI Sequence Detail	1786	Not Applicable
polypeptide	ENSMUSP00000057323	Ensembl \| MGI Sequence Detail	363	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000001674 G-protein coupled receptor 6

(term hierarchy)
InterPro Domains

IPR017452 GPCR, rhodopsin-like, 7TM

IPR000723 G protein-coupled receptor 3/6/12 orphan

IPR001151 G protein-coupled receptor 6

IPR000276 G protein-coupled receptor, rhodopsin-like
GlyGen

Q6YNI2 3 sites

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All nucleic 9

cDNA 6

Primer pair 3

Microarray probesets 3

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MGI:2143693, MGI:2685079

Summaries

All 48

Developmental Gene Expression 11

Gene Ontology 4

Phenotypes 15
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:290119 Soleilhavoup C, et al., Nolz1 expression is required in dopaminergic axon guidance and striatal innervation. Nat Commun. 2020 Jun 19;11(1):3111

TSS for Gpr6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr97395	Chr10:40948288-40948304 (-)	-15 bp
Tssr97394	Chr10:40948275-40948286 (-)	0 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24