Polq MGI Mouse Gene Detail - MGI:2155399 - polymerase (DNA directed), theta

Symbol

Polq
Name

polymerase (DNA directed), theta
Synonyms

A430110D14Rik

Feature Type

protein coding gene
IDs

MGI:2155399
NCBI Gene: 77782
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr16:36832148-36915779 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 26.32 cM, cytoband B4
Mapping Data

3 experiments

SNPs within 2kb

1841 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2155399	protein coding gene	Chr16:36832104-36922321 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022798	protein coding gene	Chr16:35429924-35523995 (+)
A/J	MGP_AJ_G0022763	protein coding gene	Chr16:33690734-33774065 (+)
AKR/J	MGP_AKRJ_G0022735	protein coding gene	Chr16:34971122-35060112 (+)
BALB/cJ	MGP_BALBcJ_G0022764	protein coding gene	Chr16:33791658-33875325 (+)
C3H/HeJ	MGP_C3HHeJ_G0022528	protein coding gene	Chr16:35089164-35184563 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023211	protein coding gene	Chr16:36275610-36362283 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020725	protein coding gene	Chr16:34052493-34132666 (+)
CAST/EiJ	MGP_CASTEiJ_G0022054	protein coding gene	Chr16:35213628-35305793 (+)
CBA/J	MGP_CBAJ_G0022499	protein coding gene	Chr16:37857506-37949597 (+)
DBA/2J	MGP_DBA2J_G0022631	protein coding gene	Chr16:33582600-33669664 (+)
FVB/NJ	MGP_FVBNJ_G0022606	protein coding gene	Chr16:33617782-33702415 (+)
LP/J	MGP_LPJ_G0022699	protein coding gene	Chr16:35138610-35235275 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022625	protein coding gene	Chr16:36927449-37014190 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023226	protein coding gene	Chr16:34920830-35016107 (+)
PWK/PhJ	MGP_PWKPhJ_G0021794	protein coding gene	Chr16:33984769-34070341 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021625	protein coding gene	Chr16:34841815-34931511 (+)
WSB/EiJ	MGP_WSBEiJ_G0022098	protein coding gene	Chr16:34983385-35070877 (+)

Human Ortholog

POLQ, DNA polymerase theta

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

POLQ, DNA polymerase theta
Synonyms

PRO0327
Links

HGNC:9186

NCBI Gene ID: 10721

neXtProt AC: NX_O75417

UniProt: O75417
Chr Location

3q13.33; chr3:121431431-121545988 (-) GRCh38

MGI Vertebrate Homology

Polq stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: POLQ
Gene Tree

Polq

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Phenotype Summary

10 phenotypes from 5 alleles in 5 genetic backgrounds
1 phenotype from multigenic genotypes
21 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (ENU)

1
Endonuclease-mediated

6
Targeted

3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

127 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Animals carrying a homozygous mutation at this locus display elevated levels of chromosomal damage.

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All GO Annotations

60
GO References

16

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

725
Tissues

14
cDNA Data

45
Literature Summary

2

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase polq

ZFIN polq

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All Sequences

56
RefSeq

11
UniProt

4
CCDS

CCDS28158.1, CCDS49845.1

Ensembl

ENSMUSG00000034206 (Evidence)
NCBI Gene

77782

			Length	Strain/Species	Flank
genomic	ENSMUSG00000034206	Ensembl Gene Model \| MGI Sequence Detail	83632	C57BL/6J	± kb
transcript	ENSMUST00000054034	Ensembl \| MGI Sequence Detail	8552	Not Applicable
polypeptide	ENSMUSP00000059757	Ensembl \| MGI Sequence Detail	2544	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000012981 DNA polymerase theta

(term hierarchy)
EC

2.7.7.49, 2.7.7.7, 3.6.4.12
InterPro Domains

IPR011545 DEAD/DEAH box helicase domain

IPR019760 DNA-directed DNA polymerase, family A, conserved site

IPR001098 DNA-directed DNA polymerase, family A, palm domain

IPR002298 DNA polymerase A

IPR046931 DNA polymerase theta-like, helix-turn-helix domain

IPR043502 DNA/RNA polymerase superfamily

IPR001650 Helicase, C-terminal domain-like

IPR050474 Helicase Hel308/SKI2

IPR014001 Helicase superfamily 1/2, ATP-binding domain

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR048960 POLQ-like, helical domain

IPR012337 Ribonuclease H-like superfamily

IPR036397 Ribonuclease H superfamily

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All nucleic 46

cDNA 45

Primer pair 1

Microarray probesets 2

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MGI:1925032

Summaries

All 55

Developmental Gene Expression 2

Gene Ontology 16

Phenotypes 21
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:348075 Shah P, et al., Primordial germ cell DNA demethylation and development require DNA translesion synthesis. Nat Commun. 2024 May 3;15(1):3734

TSS for Polq:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr138304	Chr16:36831656-36831659 (+)	-490 bp
Tssr138305	Chr16:36832120-36832153 (+)	-11 bp
Tssr138306	Chr16:36858237-36858251 (+)	26,096 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24