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Rrm2b Gene Detail
Summary
  • Symbol
    Rrm2b
  • Name
    ribonucleotide reductase M2 B (TP53 inducible)
  • Synonyms
    p53R2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2155865
    NCBI Gene: 382985
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:37924196-37961562 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 15.10 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    808 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2155865
 protein coding gene Chr15:37924196-37961562 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021804
 protein coding gene Chr15:36394879-36446374 (-)
A/J MGP_AJ_G0021764
 protein coding gene Chr15:35000990-35042631 (-)
AKR/J MGP_AKRJ_G0021744
 protein coding gene Chr15:36029589-36070843 (-)
BALB/cJ MGP_BALBcJ_G0021771
 protein coding gene Chr15:35046855-35086632 (-)
C3H/HeJ MGP_C3HHeJ_G0021545
 protein coding gene Chr15:35983333-36021257 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022210
 protein coding gene Chr15:37824625-37866411 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019747
 protein coding gene Chr15:32785477-32819777 (-)
CAST/EiJ MGP_CASTEiJ_G0021062
 protein coding gene Chr15:36379236-36416378 (-)
CBA/J MGP_CBAJ_G0021514
 protein coding gene Chr15:39032400-39072469 (-)
DBA/2J MGP_DBA2J_G0021638
 protein coding gene Chr15:34845262-34884648 (-)
FVB/NJ MGP_FVBNJ_G0021616
 protein coding gene Chr15:34246776-34285517 (-)
LP/J MGP_LPJ_G0021708
 protein coding gene Chr15:36255739-36305340 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021640
 protein coding gene Chr15:42059187-42100527 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022233
 protein coding gene Chr15:36178715-36218707 (-)
PWK/PhJ MGP_PWKPhJ_G0020806
 protein coding gene Chr15:34879403-34916866 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020644
 protein coding gene Chr15:35857598-35898842 (-)
WSB/EiJ MGP_WSBEiJ_G0021117
 protein coding gene Chr15:36117239-36160948 (-)



Homology
more
  • Human Ortholog
    RRM2B, ribonucleotide reductase regulatory TP53 inducible subunit M2B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RRM2B, ribonucleotide reductase regulatory TP53 inducible subunit M2B
  • Synonyms
    MTDPS8A, MTDPS8B, P53R2, RCDFRD
  • Links
    NCBI Gene ID: 50484
    neXtProt AC: NX_Q7LG56
    UniProt: Q7LG56

  • Chr Location
    8q22.3; chr8:102204501-102238961 (-)  GRCh38
Human Diseases
more
  • Diseases
    3 with human RRM2B associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    66 phenotypes from 4 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Loss of both functional copies of this gene results in growth retardation, multiple organ failure, and ultimately premature death due to kidney failure. Spontaneous mutation rates and apoptosis are increased in the kidneys due to an attenuation of dNTP pools and a resulting impairment of DNA repair.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    36
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    800
  • Tissues
    94
  • cDNA Data
    39
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 382985 NCBI Gene Model | MGI Sequence Detail 37367 C57BL/6J ±  kb
    transcript NM_001357022 RefSeq | MGI Sequence Detail 4778 C57BL/6  
    polypeptide Q6PEE3 UniProt | EBI | MGI Sequence Detail 351 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 39
      cDNA 39

      Microarray probesets 7
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 2
      Gene Ontology 9
      Phenotypes 22
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:302684 Molina-Jijon E, et al., Secretion of the epithelial sodium channel chaperone PCSK9 from the cortical collecting duct links sodium retention with hypercholesterolemia in nephrotic syndrome. Kidney Int. 2020 Dec;98(6):1449-1460
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory