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Wdr5 Gene Detail
Summary
  • Symbol
    Wdr5
  • Name
    WD repeat domain 5
  • Synonyms
    2410008O07Rik, Big-3, Bmp2-induced gene
  • Feature Type
    protein coding gene
  • IDs
    MGI:2155884
    NCBI Gene: 140858
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:27405169-27426547 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 19.38 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    597 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2155884
 protein coding gene Chr2:27405159-27426547 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025515
 protein coding gene Chr2:25508717-25529680 (+)
A/J MGP_AJ_G0025492
 protein coding gene Chr2:24551937-24574023 (+)
AKR/J MGP_AKRJ_G0025462
 protein coding gene Chr2:25361149-25382907 (+)
BALB/cJ MGP_BALBcJ_G0025488
 protein coding gene Chr2:24669379-24691154 (+)
C3H/HeJ MGP_C3HHeJ_G0025249
 protein coding gene Chr2:25283756-25305231 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025932
 protein coding gene Chr2:26380427-26401761 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023343
 protein coding gene Chr2:23369352-23390689 (+)
CAST/EiJ MGP_CASTEiJ_G0024712
 protein coding gene Chr2:25164717-25188783 (+)
CBA/J MGP_CBAJ_G0025227
 protein coding gene Chr2:27282032-27303059 (+)
DBA/2J MGP_DBA2J_G0025360
 protein coding gene Chr2:24367193-24388547 (+)
FVB/NJ MGP_FVBNJ_G0025322
 protein coding gene Chr2:24130399-24151868 (+)
LP/J MGP_LPJ_G0025446
 protein coding gene Chr2:25453000-25474829 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025353
 protein coding gene Chr2:27307889-27332193 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025991
 protein coding gene Chr2:25280690-25304613 (+)
PWK/PhJ MGP_PWKPhJ_G0024460
 protein coding gene Chr2:24155977-24179603 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024260
 protein coding gene Chr2:25440124-25459005 (+)
WSB/EiJ MGP_WSBEiJ_G0024781
 protein coding gene Chr2:25403002-25426558 (+)



Homology
more
  • Human Ortholog
    WDR5, WD repeat domain 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    WDR5, WD repeat domain 5
  • Synonyms
    BIG-3, BIG3, CFAP89, SWD3
  • Links
    NCBI Gene ID: 11091
    neXtProt AC: NX_P61964
    UniProt: P61964

  • Chr Location
    9q34.2; chr9:134135199-134159968 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    63
  • GO References
    21
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    727
  • Tissues
    17
  • cDNA Data
    142
  • Literature Summary
    10
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000026917 Ensembl Gene Model | MGI Sequence Detail 21379 C57BL/6J ±  kb
transcript ENSMUST00000113952 Ensembl | MGI Sequence Detail 2890 Not Applicable  
polypeptide ENSMUSP00000109585 Ensembl | MGI Sequence Detail 334 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 142
    cDNA 142

    Microarray probesets 4
Other
Accession IDs
less
MGI:1922060, MGI:2138759, MGI:2138815
References
more
  • Summaries
    All 65
    Developmental Gene Expression 10
    Gene Ontology 21
    Phenotypes 8
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:334487 Liu L, et al., Loss of Wdr5 attenuates MLL-rearranged leukemogenesis by suppressing Myc targets. Biochim Biophys Acta Mol Basis Dis. 2022 Nov 17;1869(2):166600
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory