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Il25 Gene Detail
Summary
  • Symbol
    Il25
  • Name
    interleukin 25
  • Synonyms
    Il17e, IL-17E
  • Feature Type
    protein coding gene
  • IDs
    MGI:2155888
    NCBI Gene: 140806
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:55170152-55173294 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 14, 28.00 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    125 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2155888
protein coding gene Chr14:55170152-55173294 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021332
protein coding gene Chr14:48915585-48918726 (+)
A/J MGP_AJ_G0021291
protein coding gene Chr14:47950369-47953510 (+)
AKR/J MGP_AKRJ_G0021267
protein coding gene Chr14:49695432-49698573 (+)
BALB/cJ MGP_BALBcJ_G0021295
protein coding gene Chr14:47927807-47930948 (+)
C3H/HeJ MGP_C3HHeJ_G0021075
protein coding gene Chr14:49389088-49392229 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021733
protein coding gene Chr14:51386325-51389467 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019280
protein coding gene Chr14:46363877-46367085 (+)
CAST/EiJ MGP_CASTEiJ_G0020594
protein coding gene Chr14:45628281-45631415 (+)
CBA/J MGP_CBAJ_G0021042
protein coding gene Chr14:52945345-52948486 (+)
DBA/2J MGP_DBA2J_G0021163
protein coding gene Chr14:47692381-47695522 (+)
FVB/NJ MGP_FVBNJ_G0021145
protein coding gene Chr14:47151121-47154262 (+)
LP/J MGP_LPJ_G0021237
protein coding gene Chr14:49934999-49938140 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021169
protein coding gene Chr14:52329846-52332987 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021760
protein coding gene Chr14:48872890-48876031 (+)
PWK/PhJ MGP_PWKPhJ_G0020341
protein coding gene Chr14:44227274-44230415 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020169
protein coding gene Chr14:44857745-44860907 (+)
WSB/EiJ MGP_WSBEiJ_G0020647
protein coding gene Chr14:49170360-49173501 (+)



Homology
more
  • Human Ortholog
    IL25, interleukin 25
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IL25, interleukin 25
  • Synonyms
    IL17E
  • Links
    NCBI Gene ID: 64806
    neXtProt AC: NX_Q9H293
    UniProt: Q9H293

  • Chr Location
    14q11.2; chr14:23372809-23376403 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    38 phenotypes from 6 alleles in 7 genetic backgrounds
    2 phenotypes from multigenic genotypes
    54 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele have increased susceptibility to parasitic infection. Male homozygous mutant mice exhibit notably increased mean serum triglyceride levels in another null allele.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic 140806 NCBI Gene Model | MGI Sequence Detail 3143 C57BL/6J ±  kb
    transcript NM_080729 RefSeq | MGI Sequence Detail 1064 C57BL/6  
    polypeptide Q8VHH8 UniProt | EBI | MGI Sequence Detail 169 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 5
      Genomic 1
      cDNA 4

      Microarray probesets 3
    References
    more
    • Summaries
      All 113
      Gene Ontology 8
      Phenotypes 54
    • Earliest
      J:72821 Pan G, et al., Forced Expression of Murine IL-17E Induces Growth Retardation, Jaundice, a Th2-Biased Response, and Multiorgan Inflammation in Mice. J Immunol. 2001 Dec 1;167(11):6559-67
    • Latest
      J:349170 Billipp TE, et al., Tuft cell-derived acetylcholine promotes epithelial chloride secretion and intestinal helminth clearance. Immunity. 2024 May 6;

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    12/10/2024
    MGI 6.24
    The Jackson Laboratory