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Pask Gene Detail
Summary
  • Symbol
    Pask
  • Name
    PAS domain containing serine/threonine kinase
  • Synonyms
    mKIAA0135, Paskin
  • Feature Type
    protein coding gene
  • IDs
    MGI:2155936
    NCBI Gene: 269224
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:93237165-93271237 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 47.24 cM, cytoband D
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    611 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2155936
 protein coding gene Chr1:93236492-93271237 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016339
 protein coding gene Chr1:94926777-94962432 (-)
A/J MGP_AJ_G0016320
 protein coding gene Chr1:91526704-91561412 (-)
AKR/J MGP_AKRJ_G0016281
 protein coding gene Chr1:94227546-94262217 (-)
BALB/cJ MGP_BALBcJ_G0016276
 protein coding gene Chr1:91708259-91742823 (-)
C3H/HeJ MGP_C3HHeJ_G0016105
 protein coding gene Chr1:94482124-94516827 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016735
 protein coding gene Chr1:98541112-98579980 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014453
 protein coding gene Chr1:85775570-85817329 (-)
CAST/EiJ MGP_CASTEiJ_G0015688
 protein coding gene Chr1:93813388-93850532 (-)
CBA/J MGP_CBAJ_G0016079
 protein coding gene Chr1:101729930-101772374 (-)
DBA/2J MGP_DBA2J_G0016184
 protein coding gene Chr1:90722016-90756606 (-)
FVB/NJ MGP_FVBNJ_G0016183
 protein coding gene Chr1:89796521-89831333 (-)
LP/J MGP_LPJ_G0016255
 protein coding gene Chr1:96105575-96140151 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016208
 protein coding gene Chr1:104838968-104875252 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016774
 protein coding gene Chr1:94244475-94279096 (-)
PWK/PhJ MGP_PWKPhJ_G0015473
 protein coding gene Chr1:90160147-90195128 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015257
 protein coding gene Chr1:93195662-93234271 (-)
WSB/EiJ MGP_WSBEiJ_G0015748
 protein coding gene Chr1:94064657-94100679 (-)



Homology
more
  • Human Ortholog
    PASK, PAS domain containing serine/threonine kinase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PASK, PAS domain containing serine/threonine kinase
  • Synonyms
    PASKIN, STK37
  • Links
    NCBI Gene ID: 23178
    neXtProt AC: NX_Q96RG2
    UniProt: Q96RG2

  • Chr Location
    2q37.3; chr2:241106099-241150347 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 1 allele in 2 genetic backgrounds
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display resistance to diet-induced obesity, impaired glucose stimulated insulin secretion, abnormal energy balance, and abnormalities in hypoxia induced changes in ventialtion.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    50
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    753
  • Tissues
    17
  • cDNA Data
    39
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 269224 NCBI Gene Model | MGI Sequence Detail 34073 C57BL/6J ±  kb
    transcript NM_080850 RefSeq | MGI Sequence Detail 5114 C57BL/6  
    polypeptide Q8CEE6 UniProt | EBI | MGI Sequence Detail 1383 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 40
      Genomic 1
      cDNA 39

      Microarray probesets 3
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 4
      Gene Ontology 13
      Phenotypes 22
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:348831 Xiao M, et al., PASK links cellular energy metabolism with a mitotic self-renewal network to establish differentiation competence. Elife. 2023 Apr 13;12
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory