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Lnx2 Gene Detail
Summary
  • Symbol
    Lnx2
  • Name
    ligand of numb-protein X 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2155959
    NCBI Gene: 140887
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:146953471-147013364 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 86.69 cM, cytoband G2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2232 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2155959
 protein coding gene Chr5:146953465-147013396 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030383
 protein coding gene Chr5:152641743-152705753 (-)
A/J MGP_AJ_G0030356
 protein coding gene Chr5:146179799-146242468 (-)
AKR/J MGP_AKRJ_G0030283
 protein coding gene Chr5:150666583-150728176 (-)
BALB/cJ MGP_BALBcJ_G0030365
 protein coding gene Chr5:147392597-147453737 (-)
C3H/HeJ MGP_C3HHeJ_G0030079
 protein coding gene Chr5:151632901-151696480 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030820
 protein coding gene Chr5:158225745-158291441 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028033
 protein coding gene Chr5:140594571-140655612 (-)
CAST/EiJ MGP_CASTEiJ_G0029481
 protein coding gene Chr5:151187913-151249651 (-)
CBA/J MGP_CBAJ_G0030057
 protein coding gene Chr5:164812072-164876395 (-)
DBA/2J MGP_DBA2J_G0030201
 protein coding gene Chr5:145862856-145922886 (-)
FVB/NJ MGP_FVBNJ_G0030155
 protein coding gene Chr5:145057361-145120253 (-)
LP/J MGP_LPJ_G0030288
 protein coding gene Chr5:153334922-153396109 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030191
 protein coding gene Chr5:167124709-167185634 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030850
 protein coding gene Chr5:150575908-150635777 (-)
PWK/PhJ MGP_PWKPhJ_G0029195
 protein coding gene Chr5:144942551-145004010 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029031
 protein coding gene Chr5:147897913-147959468 (-)
WSB/EiJ MGP_WSBEiJ_G0029558
 protein coding gene Chr5:151360090-151422118 (-)



Homology
more
  • Human Ortholog
    LNX2, ligand of numb-protein X 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LNX2, ligand of numb-protein X 2
  • Synonyms
    PDZRN1
  • Links
    NCBI Gene ID: 222484
    neXtProt AC: NX_Q8N448
    UniProt: Q8N448

  • Chr Location
    13q12.2; chr13:27545913-27621107 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    790
  • Tissues
    41
  • cDNA Data
    47
  • Literature Summary
    9
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 140887 NCBI Gene Model | MGI Sequence Detail 59894 C57BL/6J ±  kb
transcript NM_001424754 RefSeq | MGI Sequence Detail 4538 C57BL/6  
polypeptide Q91XL2 UniProt | EBI | MGI Sequence Detail 687 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 51
    cDNA 48
    Primer pair 1
    Other 2

    Microarray probesets 4
Other
Accession IDs
less
MGI:2141172
References
more
  • Summaries
    All 41
    Developmental Gene Expression 9
    Gene Ontology 6
    Phenotypes 11
  • Earliest
    J:73266 Rice D S, et al., The Lnx family proteins function as molecular scaffolds for Numb family proteins. Mol Cell Neurosci. 2001 Nov;18(5):525-40
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory