Ptpn7 MGI Mouse Gene Detail - MGI:2156893 - protein tyrosine phosphatase, non-receptor type 7

Symbol

Ptpn7
Name

protein tyrosine phosphatase, non-receptor type 7
Synonyms

BPTP-4, C920001D21Rik, LC-PTP

Feature Type

protein coding gene
IDs

MGI:2156893
NCBI Gene: 320139
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr1:135060438-135073055 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 58.24 cM
Mapping Data

1 experiment

SNPs within 2kb

427 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2156893	protein coding gene	Chr1:135059577-135073064 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016516	protein coding gene	Chr1:138868674-138880048 (+)
A/J	MGP_AJ_G0016499	protein coding gene	Chr1:133625693-133638160 (+)
AKR/J	MGP_AKRJ_G0016464	protein coding gene	Chr1:137602997-137615489 (+)
BALB/cJ	MGP_BALBcJ_G0016459	protein coding gene	Chr1:133939405-133952010 (+)
C3H/HeJ	MGP_C3HHeJ_G0016285	protein coding gene	Chr1:137696509-137712024 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016920	protein coding gene	Chr1:143895378-143908818 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014631	protein coding gene	Chr1:126736885-126749459 (+)
CAST/EiJ	MGP_CASTEiJ_G0015865	protein coding gene	Chr1:136770022-136783755 (+)
CBA/J	MGP_CBAJ_G0016258	protein coding gene	Chr1:148852484-148871103 (+)
DBA/2J	MGP_DBA2J_G0016364	protein coding gene	Chr1:132626919-132639831 (+)
FVB/NJ	MGP_FVBNJ_G0016363	protein coding gene	Chr1:131263768-131276552 (+)
LP/J	MGP_LPJ_G0016435	protein coding gene	Chr1:140112175-140125169 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016388	protein coding gene	Chr1:154555606-154569199 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016956	protein coding gene	Chr1:137347753-137364491 (+)
PWK/PhJ	MGP_PWKPhJ_G0015651	protein coding gene	Chr1:131649392-131660839 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015438	protein coding gene	Chr1:136311369-136323984 (+)
WSB/EiJ	MGP_WSBEiJ_G0015928	protein coding gene	Chr1:137377789-137390639 (+)

Human Ortholog

PTPN7, protein tyrosine phosphatase non-receptor type 7

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PTPN7, protein tyrosine phosphatase non-receptor type 7
Synonyms

BPTP-4, HEPTP, LC-PTP, LPTP, PTPNI
Links

HGNC:9659

NCBI Gene ID: 5778

neXtProt AC: NX_P35236

UniProt: P35236
Chr Location

1q32.1; chr1:202147013-202161588 (-) GRCh38

MGI Vertebrate Homology

Ptpn7 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: PTPN7
Gene Tree

Ptpn7

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
10 phenotype references

All Mutations and Alleles

6
Chemically induced (other)

2
Endonuclease-mediated

1
Gene trapped

1
Radiation induced

1
Targeted

1
Genomic Mutations

3 involving Ptpn7
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

24 strains or lines available

Mice homozygous for disruptions in this gene display a normal phenotype.

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All GO Annotations

16
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

729
Tissues

2
cDNA Data

30
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

45
RefSeq

8
UniProt

4
CCDS

CCDS15315.1

Ensembl

ENSMUSG00000031506 (Evidence)
NCBI Gene

320139

			Length	Strain/Species	Flank
genomic	ENSMUSG00000031506	Ensembl Gene Model \| MGI Sequence Detail	12618	C57BL/6J	± kb
transcript	ENSMUST00000187985	Ensembl \| MGI Sequence Detail	1990	Not Applicable
polypeptide	ENSMUSP00000141133	Ensembl \| MGI Sequence Detail	359	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000013462 tyrosine-protein phosphatase non-receptor type 7

(term hierarchy)
EC

3.1.3.48
InterPro Domains

IPR016130 Protein-tyrosine phosphatase, active site

IPR003595 Protein-tyrosine phosphatase, catalytic

IPR008356 Protein-tyrosine phosphatase, KIM-containing

IPR029021 Protein-tyrosine phosphatase-like

IPR000242 Tyrosine-specific protein phosphatase, PTPase domain

IPR000387 Tyrosine-specific protein phosphatases domain

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All nucleic 30

cDNA 30

Microarray probesets 1

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MGI:2443461

Summaries

All 31

Developmental Gene Expression 1

Gene Ontology 6

Phenotypes 10
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:342802 Wang N, et al., Mapping brain gene coexpression in daytime transcriptomes unveils diurnal molecular networks and deciphers perturbation gene signatures. Neuron. 2022 Oct 19;110(20):3318-3338.e9

TSS for Ptpn7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr8930	Chr1:135059547-135059597 (+)	-866 bp
Tssr8931	Chr1:135060431-135060479 (+)	17 bp
Tssr8932	Chr1:135060996-135061007 (+)	564 bp
Tssr8933	Chr1:135061010-135061057 (+)	596 bp
Tssr8934	Chr1:135061591-135061623 (+)	1,169 bp
Tssr8935	Chr1:135070406-135070409 (+)	9,970 bp
Tssr8936	Chr1:135072066-135072091 (+)	11,641 bp
Tssr8937	Chr1:135072313-135072331 (+)	11,884 bp
Tssr8938	Chr1:135072345-135072402 (+)	11,936 bp
Tssr8939	Chr1:135072422-135072444 (+)	11,995 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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