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Dppa4 Gene Detail
Summary
  • Symbol
    Dppa4
  • Name
    developmental pluripotency associated 4
  • Synonyms
    2410091M23Rik, ECAT15-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2157525
    NCBI Gene: 73693
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:48104096-48114600 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 30.75 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    395 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2157525
 protein coding gene Chr16:48104096-48114655 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022863
 protein coding gene Chr16:47128923-47140611 (+)
A/J MGP_AJ_G0022829
 protein coding gene Chr16:45058994-45070579 (+)
AKR/J MGP_AKRJ_G0022801
 protein coding gene Chr16:46560811-46571044 (+)
BALB/cJ MGP_BALBcJ_G0022830
 protein coding gene Chr16:45103030-45113477 (+)
C3H/HeJ MGP_C3HHeJ_G0022594
 protein coding gene Chr16:46643914-46655137 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023277
 protein coding gene Chr16:48297252-48310394 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020790
 protein coding gene Chr16:45207759-45218303 (+)
CAST/EiJ MGP_CASTEiJ_G0022119
 protein coding gene Chr16:46894269-46907170 (+)
CBA/J MGP_CBAJ_G0022566
 protein coding gene Chr16:50197737-50213520 (+)
DBA/2J MGP_DBA2J_G0022697
 protein coding gene Chr16:44776418-44786692 (+)
FVB/NJ MGP_FVBNJ_G0022673
 protein coding gene Chr16:44660285-44669822 (+)
LP/J MGP_LPJ_G0022765
 protein coding gene Chr16:46887773-46898173 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022691
 protein coding gene Chr16:49893720-49906627 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023292
 protein coding gene Chr16:46552955-46563373 (+)
PWK/PhJ MGP_PWKPhJ_G0021859
 protein coding gene Chr16:45125327-45136992 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021689
 protein coding gene Chr16:46447957-46462931 (+)
WSB/EiJ MGP_WSBEiJ_G0022164
 protein coding gene Chr16:46605829-46618034 (+)



Homology
more
  • Human Ortholog
    DPPA4, developmental pluripotency associated 4
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DPPA4, developmental pluripotency associated 4
  • Synonyms
    2410091M23Rik
  • Links
    NCBI Gene ID: 55211
    neXtProt AC: NX_Q7L190
    UniProt: Q7L190

  • Chr Location
    3q13.13; chr3:109326144-109339636 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 3 alleles in 2 genetic backgrounds
    16 phenotypes from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit perinatal and postnatal lethality, abnormal lung morphology, skeletal defects, and a maternal effect on female fertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    844
  • Tissues
    47
  • cDNA Data
    31
  • Literature Summary
    20
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000058550 Ensembl Gene Model | MGI Sequence Detail 10505 C57BL/6J ±  kb
    transcript ENSMUST00000096045 Ensembl | MGI Sequence Detail 1479 Not Applicable  
    polypeptide ENSMUSP00000093749 Ensembl | MGI Sequence Detail 296 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000006667 developmental pluripotency-associated protein 4
      (term hierarchy)
    • InterPro Domains
      IPR039590 Developmental pluripotency-associated protein 2/4
      IPR025891 Developmental pluripotency-associated protein 2/4, C-terminal domain
    • GlyGen
      Q8CCG4 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 36
      cDNA 31
      Primer pair 5

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1920943, MGI:2146696
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 20
      Gene Ontology 3
      Phenotypes 11
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:344223 Zhang W, et al., NLRP14 deficiency causes female infertility with oocyte maturation defects and early embryonic arrest by impairing cytoplasmic UHRF1 abundance. Cell Rep. 2023 Dec 26;42(12):113531
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory