Idd5.2 QTL Detail

Summary

• Symbol
  Idd5.2
• Name
  insulin dependent diabetes susceptibility 5.2
• Synonyms
  Idd5.2, Idd5b

• Feature Type
  QTL
• IDs
  MGI:2158434
  NCBI Gene: 170802
• Candidate Genes
  1 Gene

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 1, cM position of peak correlated region/marker: Syntenic
• QTL Archive
  Reifsnyder2 download
• Mapping Data
  4 experiments

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  1 phenotype from 1 allele in 1 genetic background
  2 phenotypes from multigenic genotypes
  7 phenotype references
  

• All Mutations and Alleles
  2
• QTL
  2
• Find Mice (IMSR)
  5 strains or lines available

Sequences &
Gene Models

• NCBI Gene
  170802

References

• Summaries
  All 16

  Phenotypes 7
• Earliest
  J:88667 Hill NJ, et al., NOD Idd5 locus controls insulitis and diabetes and overlaps the orthologous CTLA4/IDDM12 and NRAMP1 loci in humans. Diabetes. 2000 Oct;49(10):1744-7
• Latest
  J:213816 Kochupurakkal NM, et al., Blockade of the programmed death-1 (PD1) pathway undermines potent genetic protection from type 1 diabetes. PLoS One. 2014;9(2):e89561

Candidate Genes for Idd5.2:

Gene	Genome Location (GRCm39)	Reference	QTL Note
Slc11a1	Chr1:74414354-74425221 (+)	J:107559	Congenic mouse strains within the Idd5.2 (MGI: Idd5b) region of mouse Chromosome 1 were utilized to suggest that solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 (Slc11a1) is a likely candidate for Idd5.2. Using RNAi (RNA interference) the authors showed that a knockdown of Slc11a1 (allele Nramp1) had a detectable effect on diabetes incidence conferred within the Idd5.2 region.