Idh3b MGI Mouse Gene Detail - MGI:2158650 - isocitrate dehydrogenase 3 (NAD+) beta

Symbol

Idh3b
Name

isocitrate dehydrogenase 3 (NAD+) beta

Feature Type

protein coding gene
IDs

MGI:2158650
NCBI Gene: 170718
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr2:130121229-130126371 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 63.20 cM, cytoband F3
Mapping Data

2 experiments

SNPs within 2kb

208 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2158650	protein coding gene	Chr2:130121229-130126467 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0026498	protein coding gene	Chr2:133728051-133733283 (-)
A/J	MGP_AJ_G0026462	protein coding gene	Chr2:128318226-128323463 (-)
AKR/J	MGP_AKRJ_G0026437	protein coding gene	Chr2:132001485-132006717 (-)
BALB/cJ	MGP_BALBcJ_G0026474	protein coding gene	Chr2:128675553-128680763 (-)
C3H/HeJ	MGP_C3HHeJ_G0026217	protein coding gene	Chr2:132453571-132458788 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0026919	protein coding gene	Chr2:137869465-137874709 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024296	protein coding gene	Chr2:123062403-123067585 (-)
CAST/EiJ	MGP_CASTEiJ_G0025678	protein coding gene	Chr2:132704061-132709245 (-)
CBA/J	MGP_CBAJ_G0026197	protein coding gene	Chr2:142976346-142981563 (-)
DBA/2J	MGP_DBA2J_G0026331	protein coding gene	Chr2:127706203-127711765 (-)
FVB/NJ	MGP_FVBNJ_G0026295	protein coding gene	Chr2:126328426-126333643 (-)
LP/J	MGP_LPJ_G0026436	protein coding gene	Chr2:133992537-133997828 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026315	protein coding gene	Chr2:146827982-146833230 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026974	protein coding gene	Chr2:131972504-131978805 (-)
PWK/PhJ	MGP_PWKPhJ_G0025414	protein coding gene	Chr2:127260514-127265708 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0025216	protein coding gene	Chr2:131090858-131096060 (-)
WSB/EiJ	MGP_WSBEiJ_G0025752	protein coding gene	Chr2:132897443-132904099 (-)

Human Ortholog

IDH3B, isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

IDH3B, isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta
Synonyms

RP46
Links

HGNC:5385

NCBI Gene ID: 3420

neXtProt AC: NX_O43837

UniProt: O43837
Chr Location

20p13; chr20:2658395-2664219 (-) GRCh38

MGI Vertebrate Homology

Idh3b stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: IDH3B
Gene Tree

Idh3b

Diseases

1 with human IDH3B associations

				Human Disease	Mouse Models
				retinitis pigmentosa 46 IDs retinitis pigmentosa 46 DOID:0110409 ICD10CM:H35.5 MESH:C567249 OMIM:612572

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

8 phenotypes from 2 alleles in 2 genetic backgrounds
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

2
Radiation induced

1
Targeted

1
Genomic Mutations

2 involving Idh3b
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

26 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous knockout does not cause eye phenotypes.

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All GO Annotations

13
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

830
Tissues

100
cDNA Data

8
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase idh3b

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All Sequences

52
RefSeq

4
UniProt

3
CCDS

CCDS16738.1

Ensembl

ENSMUSG00000027406 (Evidence)
NCBI Gene

170718

			Length	Strain/Species	Flank
genomic	170718	NCBI Gene Model \| MGI Sequence Detail	5143	C57BL/6J	± kb
transcript	NM_130884	RefSeq \| MGI Sequence Detail	1520	C57BL/6
polypeptide	NP_570954	RefSeq \| MGI Sequence Detail	384	C57BL/6

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UniProt

3 Sequences
Protein Ontology

PR:000008890 isocitrate dehydrogenase [NAD] subunit beta, mitochondrial

(term hierarchy)
InterPro Domains

IPR004434 Isocitrate dehydrogenase NAD-dependent

IPR019818 Isocitrate/isopropylmalate dehydrogenase, conserved site

IPR024084 Isopropylmalate dehydrogenase-like domain
GlyGen

Q91VA7 1 site, 1 O-linked glycan (1 site)

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All nucleic 10

cDNA 8

Primer pair 2

Microarray probesets 7

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MGI:2139470

Summaries

All 43

Developmental Gene Expression 4

Gene Ontology 9

Phenotypes 13
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Idh3b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr26290	Chr2:130126342-130126371 (-)	14 bp
Tssr26289	Chr2:130121549-130121572 (-)	4,810 bp
Tssr26288	Chr2:130121395-130121412 (-)	4,967 bp
Tssr26287	Chr2:130121295-130121343 (-)	5,052 bp
Tssr26286	Chr2:130121278-130121294 (-)	5,085 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24