Acot2 MGI Mouse Gene Detail - MGI:2159605

Symbol

Acot2
Name

acyl-CoA thioesterase 2
Synonyms

Mte1, MTE-I

Feature Type

protein coding gene
IDs

MGI:2159605
NCBI Gene: 171210
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr12:84034635-84040647 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 38.99 cM, cytoband D3
Mapping Data

3 experiments

SNPs within 2kb

311 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2159605	protein coding gene	Chr12:84034635-84040651 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019922	protein coding gene	Chr12:84679698-84688635 (+)
A/J	MGP_AJ_G0019879	protein coding gene	Chr12:81445869-81454660 (+)
AKR/J	MGP_AKRJ_G0019855	protein coding gene	Chr12:83655594-83661873 (+)
BALB/cJ	MGP_BALBcJ_G0019859	protein coding gene	Chr12:81789028-81795497 (+)
C3H/HeJ	MGP_C3HHeJ_G0019665	protein coding gene	Chr12:84115204-84125336 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020311	protein coding gene	Chr12:87108649-87124941 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017929	protein coding gene	Chr12:78391412-78399562 (+)
CAST/EiJ	MGP_CASTEiJ_G0019215	protein coding gene	Chr12:79058850-79065233 (+)
CBA/J	MGP_CBAJ_G0019636	protein coding gene	Chr12:90413153-90426636 (+)
DBA/2J	MGP_DBA2J_G0019751	protein coding gene	Chr12:80990770-80997485 (+)
FVB/NJ	MGP_FVBNJ_G0019737	protein coding gene	Chr12:79965772-79974854 (+)
LP/J	MGP_LPJ_G0019823	protein coding gene	Chr12:84561357-84569584 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019776	protein coding gene	Chr12:93391855-93399582 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020345	protein coding gene	Chr12:83245691-83254360 (+)
PWK/PhJ	MGP_PWKPhJ_G0018978	protein coding gene	Chr12:75471663-75479728 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018773	protein coding gene	Chr12:77729285-77736565 (+)
WSB/EiJ	MGP_WSBEiJ_G0019267	protein coding gene	Chr12:83927625-83932880 (+)

Human Ortholog

ACOT2, acyl-CoA thioesterase 2

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ACOT2, acyl-CoA thioesterase 2
Synonyms

CTE1A, CTE-IA, MTE1, PTE2, PTE2A, ZAP128
Links

HGNC:18431

NCBI Gene ID: 10965

neXtProt AC: NX_P49753

UniProt: P49753
Chr Location

14q24.3; chr14:73567620-73575658 (+) GRCh38

MGI Vertebrate Homology

Acot2 stringent orthology
1 human;1 mouse;1 rat;3 zebrafish
HCOP

vertebrate homology predictions: ACOT2
Protein SuperFamily

Acyl-CoA_hydro
Gene Tree

Acot2

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Chemically induced (other)

1
Endonuclease-mediated

2
Targeted

2
Genomic Mutations

1 involving Acot2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

18 strains or lines available

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All GO Annotations

19
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

804
Tissues

96
cDNA Data

19
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase acot2

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All Sequences

35
RefSeq

2
UniProt

2
CCDS

CCDS26034.1

Ensembl

ENSMUSG00000021226 (Evidence)
NCBI Gene

171210

			Length	Strain/Species	Flank
genomic	ENSMUSG00000021226	Ensembl Gene Model \| MGI Sequence Detail	6013	C57BL/6J	± kb
transcript	ENSMUST00000021649	Ensembl \| MGI Sequence Detail	2196	Not Applicable
polypeptide	ENSMUSP00000021649	Ensembl \| MGI Sequence Detail	453	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000003636 acyl-coenzyme A thioesterase 2, mitochondrial

(term hierarchy)
EC

3.1.2.2
InterPro Domains

IPR016662 Acyl-CoA thioesterase, long chain

IPR042490 Acyl-CoA thioester hydrolase/BAAT, N-terminal

IPR006862 Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase

IPR029058 Alpha/Beta hydrolase fold

IPR014940 BAAT/Acyl-CoA thioester hydrolase C-terminal
GlyGen

Q9QYR9 1 site, 1 O-linked glycan (1 site)

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All nucleic 21

cDNA 19

Primer pair 2

Microarray probesets 5

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MGI:3035001

Summaries

All 42

Developmental Gene Expression 3

Gene Ontology 9

Phenotypes 7
Earliest

J:59046 Hunt MC, et al., Peroxisome proliferator-induced long chain acyl-CoA thioesterases comprise a highly conserved novel multi-gene family involved in lipid metabolism. J Biol Chem. 1999 Nov 26;274(48):34317-26
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Acot2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr114300	Chr12:84034427-84034450 (+)	-196 bp
Tssr114301	Chr12:84034458-84034499 (+)	-156 bp
Tssr114302	Chr12:84034504-84034527 (+)	-119 bp
Tssr114303	Chr12:84034574-84034601 (+)	-47 bp
Tssr114304	Chr12:84034628-84034672 (+)	15 bp
Tssr114305	Chr12:84034681-84034692 (+)	52 bp
Tssr114306	Chr12:84040031-84040035 (+)	5,398 bp
Tssr114307	Chr12:84040174-84040187 (+)	5,546 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24