Arr3 MGI Mouse Gene Detail - MGI:2159617

Symbol

Arr3
Name

arrestin 3, retinal
Synonyms

Arr4, arrestin 4, CAR, cone arrestin, mCAR, mCARFL, X-arrestin

Feature Type

protein coding gene
IDs

MGI:2159617
NCBI Gene: 170735
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

ChrX:99649103-99662099 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 43.72 cM, cytoband C2
Mapping Data

1 experiment

SNPs within 2kb

382 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2159617	protein coding gene	ChrX:99649086-99662099 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0035945	protein coding gene	ChrX:97064988-97077992 (+)
A/J	MGP_AJ_G0035930	protein coding gene	ChrX:97108658-97121636 (+)
AKR/J	MGP_AKRJ_G0035846	protein coding gene	ChrX:99891792-99906938 (+)
BALB/cJ	MGP_BALBcJ_G0035913	protein coding gene	ChrX:95852862-95865846 (+)
C3H/HeJ	MGP_C3HHeJ_G0035622	protein coding gene	ChrX:97496889-97509863 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0036442	protein coding gene	ChrX:99977437-99990410 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0033272	protein coding gene	ChrX:94883145-94896033 (+)
CAST/EiJ	MGP_CASTEiJ_G0034909	protein coding gene	ChrX:81799788-81812842 (+)
CBA/J	MGP_CBAJ_G0035597	protein coding gene	ChrX:103071902-103084889 (+)
DBA/2J	MGP_DBA2J_G0035751	protein coding gene	ChrX:96314501-96327479 (+)
FVB/NJ	MGP_FVBNJ_G0035689	protein coding gene	ChrX:95713718-95726889 (+)
LP/J	MGP_LPJ_G0035841	protein coding gene	ChrX:98038274-98059974 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035724	protein coding gene	ChrX:107602458-107615566 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0036469	protein coding gene	ChrX:96781131-96794762 (+)
PWK/PhJ	MGP_PWKPhJ_G0034608	protein coding gene	ChrX:79419962-79433271 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0034436	protein coding gene	ChrX:82684096-82700270 (+)
WSB/EiJ	MGP_WSBEiJ_G0035048	protein coding gene	ChrX:95498590-95511585 (+)

Human Ortholog

ARR3, arrestin 3

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ARR3, arrestin 3
Synonyms

ARRX, cArr, MYP26
Links

HGNC:710

NCBI Gene ID: 407

neXtProt AC: NX_P36575

UniProt: P36575
Chr Location

Xq13.1; chrX:70268305-70281883 (+) GRCh38

MGI Vertebrate Homology

Arr3 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: ARR3
Gene Tree

Arr3

Diseases

1 with human ARR3 associations

				Human Disease	Mouse Models
				myopia IDs myopia DOID:11830 ICD10CM:H52.1 ICD9CM:367.1 MESH:D009216 NCI:C102533 OMIM:160700 OMIM:255500 OMIM:300613 OMIM:310460 OMIM:603221 OMIM:608367 OMIM:608474 OMIM:608908 OMIM:609256 OMIM:609257 OMIM:609258 OMIM:609259 OMIM:609994 OMIM:609995 OMIM:610320 OMIM:612554 OMIM:612717 OMIM:613959 OMIM:613969 OMIM:614166 OMIM:614167 OMIM:615420 OMIM:615431 OMIM:615946 UMLS_CUI:C0027092

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

4 phenotypes from 2 alleles in 2 genetic backgrounds
1 phenotype from multigenic genotypes
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

2
Targeted

5
Find Mice (IMSR)

11 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Mice homozygous for a null allele exhibit normal cone electrophysiology.

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All GO Annotations

15
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

791
Tissues

12
cDNA Data

14
Literature Summary

55

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA ARR3

Xenbase arr3

ZFIN arr3a, arr3b

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All Sequences

79
RefSeq

45
UniProt

3
CCDS

CCDS41075.1

Ensembl

ENSMUSG00000060890 (Evidence)
NCBI Gene

170735

			Length	Strain/Species	Flank
genomic	ENSMUSG00000060890	Ensembl Gene Model \| MGI Sequence Detail	12997	C57BL/6J	± kb
transcript	ENSMUST00000113769	Ensembl \| MGI Sequence Detail	1359	Not Applicable
polypeptide	ENSMUSP00000109398	Ensembl \| MGI Sequence Detail	381	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000004318 arrestin-C

(term hierarchy)
InterPro Domains

IPR000698 Arrestin

IPR017864 Arrestin, conserved site

IPR011022 Arrestin C-terminal-like domain

IPR014752 Arrestin-like, C-terminal

IPR011021 Arrestin-like, N-terminal

IPR014753 Arrestin, N-terminal

IPR014756 Immunoglobulin E-set

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All nucleic 18

cDNA 14

Primer pair 4

Microarray probesets 3

Summaries

All 99

Developmental Gene Expression 55

Gene Ontology 9

Phenotypes 14
Earliest

J:61371 Hong DH, et al., A retinitis pigmentosa GTPase regulator (RPGR)-deficient mouse model for X-linked retinitis pigmentosa (RP3). Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3649-54
Latest

J:351037 Mehta K, et al., A cis-regulatory module underlies retinal ganglion cell genesis and axonogenesis. Cell Rep. 2024 Jun 25;43(6):114291

TSS for Arr3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr161614	ChrX:99649141-99649154 (+)	45 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24