Acot3 MGI Mouse Gene Detail - MGI:2159619

Symbol

Acot3
Name

acyl-CoA thioesterase 3
Synonyms

Pte2a, PTE-Ia

Feature Type

protein coding gene
IDs

MGI:2159619
NCBI Gene: 171281
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr12:84098918-84107174 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 39.02 cM, cytoband D3
Mapping Data

4 experiments

SNPs within 2kb

333 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2159619	protein coding gene	Chr12:84098918-84107176 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019925	protein coding gene	Chr12:84733913-84741745 (+)
A/J	MGP_AJ_G0019882	protein coding gene	Chr12:81517586-81525007 (+)
AKR/J	MGP_AKRJ_G0019858	protein coding gene	Chr12:83729341-83738470 (+)
BALB/cJ	MGP_BALBcJ_G0019862	protein coding gene	Chr12:81855038-81863070 (+)
C3H/HeJ	MGP_C3HHeJ_G0019668	protein coding gene	Chr12:84199482-84206909 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020313	protein coding gene	Chr12:87163925-87172555 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017931	protein coding gene	Chr12:78440171-78447203 (+)
CAST/EiJ	MGP_CASTEiJ_G0019217	protein coding gene	Chr12:79136281-79144132 (+)
CBA/J	MGP_CBAJ_G0019639	protein coding gene	Chr12:90503908-90513806 (+)
DBA/2J	MGP_DBA2J_G0019754	protein coding gene	Chr12:81057268-81064972 (+)
FVB/NJ	MGP_FVBNJ_G0019740	protein coding gene	Chr12:80010996-80018416 (+)
LP/J	MGP_LPJ_G0019826	protein coding gene	Chr12:84607781-84616535 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019779	protein coding gene	Chr12:93465916-93474399 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020347	protein coding gene	Chr12:83332204-83340353 (+)
PWK/PhJ	MGP_PWKPhJ_G0018981	protein coding gene	Chr12:75548633-75556447 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018776	protein coding gene	Chr12:77809697-77818504 (+)
WSB/EiJ	MGP_WSBEiJ_G0019269	protein coding gene	Chr12:84000158-84007563 (+)

Human Ortholog

ACOT1, acyl-CoA thioesterase 1

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ACOT1, acyl-CoA thioesterase 1
Synonyms

ACH2, CTE-1, LACH2
Links

HGNC:33128

NCBI Gene ID: 641371

neXtProt AC: NX_Q86TX2

UniProt: Q86TX2
Chr Location

chr14:73490933-73543796 (+) GRCh38

MGI Vertebrate Homology

Acot3 stringent orthology
1 human;1 mouse;1 rat;3 zebrafish
HCOP

vertebrate homology predictions: ACOT1
Protein SuperFamily

Acyl-CoA_hydro
Gene Tree

Acot3

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
5 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

2
Chemically induced (other)

1
Endonuclease-mediated

1
Genomic Mutations

1 involving Acot3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

18 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

19
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

800
Tissues

94
cDNA Data

5
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

40
RefSeq

4
UniProt

3
CCDS

CCDS26036.1, CCDS83985.1

Ensembl

ENSMUSG00000021228 (Evidence)
NCBI Gene

171281

			Length	Strain/Species	Flank
genomic	171281	NCBI Gene Model \| MGI Sequence Detail	8257	C57BL/6J	± kb
transcript	NM_001346701	RefSeq \| MGI Sequence Detail	2689	C57BL/6
polypeptide	Q9QYR7	UniProt \| EBI \| MGI Sequence Detail	432	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000004545 acyl-coenzyme A thioesterase 3

(term hierarchy)
EC

3.1.2.2
InterPro Domains

IPR016662 Acyl-CoA thioesterase, long chain

IPR042490 Acyl-CoA thioester hydrolase/BAAT, N-terminal

IPR006862 Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase

IPR029058 Alpha/Beta hydrolase fold

IPR014940 BAAT/Acyl-CoA thioester hydrolase C-terminal

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All nucleic 5

cDNA 5

Microarray probesets 2

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MGI:2145005

Summaries

All 27

Developmental Gene Expression 1

Gene Ontology 6

Phenotypes 5
Earliest

J:59046 Hunt MC, et al., Peroxisome proliferator-induced long chain acyl-CoA thioesterases comprise a highly conserved novel multi-gene family involved in lipid metabolism. J Biol Chem. 1999 Nov 26;274(48):34317-26
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Acot3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr114312	Chr12:84098888-84098919 (+)	-14 bp
Tssr114313	Chr12:84098921-84098931 (+)	8 bp
Tssr114314	Chr12:84098949-84098958 (+)	36 bp
Tssr114315	Chr12:84100123-84100157 (+)	1,222 bp
Tssr114316	Chr12:84100213-84100224 (+)	1,301 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24