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Arid5b Gene Detail
Summary
  • Symbol
    Arid5b
  • Name
    AT-rich interaction domain 5B
  • Synonyms
    5430435G07Rik, Desrt, Mrf2, Mrf2alpha, Mrf2beta
  • Feature Type
    protein coding gene
  • IDs
    MGI:2175912
    NCBI Gene: 71371
  • Alliance
    gene page
  • Transcription Start Sites
    44 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:67928350-68114570 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 35.14 cM, cytoband B5.1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4266 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2175912
 protein coding gene Chr10:67928350-68114596 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017329
 protein coding gene Chr10:67887290-68085290 (-)
A/J MGP_AJ_G0017306
 protein coding gene Chr10:65613174-65797520 (-)
AKR/J MGP_AKRJ_G0017267
 protein coding gene Chr10:67401763-67584281 (-)
BALB/cJ MGP_BALBcJ_G0017266
 protein coding gene Chr10:65821170-66003572 (-)
C3H/HeJ MGP_C3HHeJ_G0017090
 protein coding gene Chr10:67403540-67591373 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017724
 protein coding gene Chr10:70322591-70523657 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015414
 protein coding gene Chr10:62302387-62485980 (-)
CAST/EiJ MGP_CASTEiJ_G0016660
 protein coding gene Chr10:67463756-67665774 (-)
CBA/J MGP_CBAJ_G0017062
 protein coding gene Chr10:73009304-73208965 (-)
DBA/2J MGP_DBA2J_G0017167
 protein coding gene Chr10:64999262-65179902 (-)
FVB/NJ MGP_FVBNJ_G0017160
 protein coding gene Chr10:64164319-64345173 (-)
LP/J MGP_LPJ_G0017240
 protein coding gene Chr10:68309591-68500117 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017188
 protein coding gene Chr10:75215314-75402753 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017763
 protein coding gene Chr10:67299987-67482852 (-)
PWK/PhJ MGP_PWKPhJ_G0016444
 protein coding gene Chr10:64798561-64986561 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016226
 protein coding gene Chr10:66678751-66864390 (-)
WSB/EiJ MGP_WSBEiJ_G0016724
 protein coding gene Chr10:67244262-67437298 (-)



Homology
more
  • Human Ortholog
    ARID5B, AT-rich interaction domain 5B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ARID5B, AT-rich interaction domain 5B
  • Synonyms
    DESRT, MRF-2, MRF2
  • Links
    NCBI Gene ID: 84159
    neXtProt AC: NX_Q14865
    UniProt: Q14865

  • Chr Location
    10q21.2; chr10:61901684-62096944 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    75 phenotypes from 3 alleles in 6 genetic backgrounds
    12 phenotypes from multigenic genotypes
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene experience a high level of mortality perinatally or earlier. Growth rates are low and mice remain small throughout live. There are abnormalities in various organ systems as well as the reproductive system. Fertility is reduced.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    32
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    914
  • Tissues
    145
  • cDNA Data
    14
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000019947 Ensembl Gene Model | MGI Sequence Detail 186221 C57BL/6J ±  kb
    transcript ENSMUST00000219238 Ensembl | MGI Sequence Detail 7581 Not Applicable  
    polypeptide ENSMUSP00000151227 Ensembl | MGI Sequence Detail 1188 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000004270 AT-rich interactive domain-containing protein 5B
      (term hierarchy)
    • InterPro Domains
      IPR001606 ARID DNA-binding domain
      IPR036431 ARID DNA-binding domain superfamily
      IPR030408 AT-rich interactive domain-containing protein 5B, ARID/BRIGHT DNA binding domain
      IPR051232 AT-rich Interactive Domain/SWI1 Chromatin Remodeling
      IPR043151 Bromo adjacent homology (BAH) domain superfamily
    • GlyGen
      Q8BM75 3 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 18
      Genomic 2
      cDNA 14
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1918621, MGI:2143624
    References
    more
    • Summaries
      All 68
      Developmental Gene Expression 12
      Gene Ontology 12
      Phenotypes 27
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:347804 Chalise JP, et al., ARID5B regulates fatty acid metabolism and proliferation at the Pre-B cell stage during B cell development. Front Immunol. 2023;14:1170475
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory