Tg(MMTV-cre)1Mam
Transgene Detail

Summary

• Symbol: Tg(MMTV-cre)1Mam
• Name: transgene insertion 1, Lothar Hennighausen
• MGI ID: MGI:2176165
• Synonyms: A1 line, A-line, CreA, MMTV-Cre, MMTV-CreA, MMTV Cre line A, MMTV-Cre^lineA
• Transgene: Tg(MMTV-cre)1Mam Location: unknown
• Alliance: Tg(MMTV-cre)1Mam page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(MMTV-cre)1Mam expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  virus	MMTV

• Mutation details: This transgene directs the expression of Cre recombinase under the control of the mouse mammary tumor virus (MMTV) long terminal repeat. The viral MMTV promoter directed expression of Cre recombinase in the secretory epithelium of the mammary gland, the salivary gland and in the female germline. High levels of recombination have been detected in the virgin and lactating mammary gland, salivary gland, seminal vesicle, skin, and various cells of the immune system. Little background recombination was observed in the lung, kidney, liver and brain tissues. (J:67925, J:74366)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	MMTV (virus) Summary of all recombinase alleles driven by MMTV.

Disease models

Expression

In Mice Carrying this Mutation:

104046 assay results 6 RNA-Seq or microarray experiment(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(MMTV-cre)1Mam

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

This transgene is the A line. Line 4 (D) and line F were also produced.

References

• Original: J:67925 Wagner KU, et al., Cre-mediated gene deletion in the mammary gland. Nucleic Acids Res. 1997 Nov 1;25(21):4323-30
• All: 93 reference(s)