Tg(Ins2-cre)25Mgn
Transgene Detail

Summary

• Symbol: Tg(Ins2-cre)25Mgn
• Name: transgene insertion 25, Mark A Magnuson
• MGI ID: MGI:2176227
• Synonyms: Ins2cre, Ins-Cre, M line, RIP2-cre, RIP2^Cre, Rip-cre, [RIP]-Cre, RIP Cre, RIP-Cre, RIPCre, TgN(ins2-Cre)25Mgn
• Transgene: Tg(Ins2-cre)25Mgn Location: Chr7:62640905-62658305 bp Genetic Position: Chr7, Syntenic
• Alliance: Tg(Ins2-cre)25Mgn page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA)F2

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutations: Duplication, Insertion
• Tg(Ins2-cre)25Mgn expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  rat

  Ins2 (24506)

  Ins2	(MGI:96573)

• Mutation details: This transgene expresses Cre recombinase with a human growth hormone polyadenylation signal under the control of the rat insulin promoter (Ins2), which is active in pancreatic beta cells and in neurons of the hypothalamus. 9 copies of the transgene are estimated to be present. Transgene insertion occurred on Chr 7, causing a 17400 bp duplication. (J:51826)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Ins2 (rat) Summary of all recombinase alleles driven by Ins2. Comparative matrix view of recombinase activities Alliance rat Ins2 gene page

Disease models

Expression

In Mice Carrying this Mutation:	104041 assay results 7 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(Ins2-cre)25Mgn

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

References

• Original: J:51826 Postic C, et al., Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase. J Biol Chem. 1999 Jan 1;274(1):305-15
• All: 290 reference(s)