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Bmf Gene Detail
Summary
  • Symbol
    Bmf
  • Name
    BCL2 modifying factor
  • Feature Type
    protein coding gene
  • IDs
    MGI:2176433
    NCBI Gene: 171543
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:118359238-118380168 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 59.40 cM, cytoband E5
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    461 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2176433
 protein coding gene Chr2:118359238-118385240 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026316
 protein coding gene Chr2:121216265-121237042 (-)
A/J MGP_AJ_G0026277
 protein coding gene Chr2:116300249-116322104 (-)
AKR/J MGP_AKRJ_G0026256
 protein coding gene Chr2:119560278-119581185 (-)
BALB/cJ MGP_BALBcJ_G0026290
 protein coding gene Chr2:116555479-116577962 (-)
C3H/HeJ MGP_C3HHeJ_G0026036
 protein coding gene Chr2:120018737-120040457 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026737
 protein coding gene Chr2:125228579-125251081 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024117
 protein coding gene Chr2:111346848-111367383 (-)
CAST/EiJ MGP_CASTEiJ_G0025498
 protein coding gene Chr2:120324689-120349088 (-)
CBA/J MGP_CBAJ_G0026012
 protein coding gene Chr2:129650260-129672196 (-)
DBA/2J MGP_DBA2J_G0026151
 protein coding gene Chr2:115719853-115741210 (-)
FVB/NJ MGP_FVBNJ_G0026113
 protein coding gene Chr2:114544972-114568700 (-)
LP/J MGP_LPJ_G0026252
 protein coding gene Chr2:121542334-121564457 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026132
 protein coding gene Chr2:134016848-134039553 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026792
 protein coding gene Chr2:119681689-119702848 (-)
PWK/PhJ MGP_PWKPhJ_G0025234
 protein coding gene Chr2:115273416-115294573 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025033
 protein coding gene Chr2:118839455-118864215 (-)
WSB/EiJ MGP_WSBEiJ_G0025567
 protein coding gene Chr2:120501401-120523225 (-)



Homology
more
  • Human Ortholog
    BMF, Bcl2 modifying factor
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BMF, Bcl2 modifying factor
  • Links
    NCBI Gene ID: 90427
    neXtProt AC: NX_Q96LC9
    UniProt: Q96LC9

  • Chr Location
    15q15.1; chr15:40087890-40108892 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotypes from 4 alleles in 5 genetic backgrounds
    11 phenotypes from multigenic genotypes
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for targeted knockout mutations show enlarged spleen, increased B cells and CD8-positive T cells, decreased B cells and T cells apoptosis, vagina atresia and hydrometrocolpos.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    716
  • Tissues
    3
  • cDNA Data
    51
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000040093 Ensembl Gene Model | MGI Sequence Detail 20931 C57BL/6J ±  kb
    transcript ENSMUST00000090219 Ensembl | MGI Sequence Detail 4642 Not Applicable  
    polypeptide ENSMUSP00000087686 Ensembl | MGI Sequence Detail 271 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 52
      cDNA 51
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2139336, MGI:2139345
    References
    more
    • Summaries
      All 69
      Developmental Gene Expression 8
      Gene Ontology 10
      Phenotypes 30
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:337771 El-Saafin F, et al., Loss of TAF8 causes TFIID dysfunction and p53-mediated apoptotic neuronal cell death. Cell Death Differ. 2022 May;29(5):1013-1027
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory