cir Gene Detail

Summary

• Symbol
  cir
• Name
  circling

• Feature Type
  heritable phenotypic marker
• IDs
  MGI:2176711
  NCBI Gene: 191577
• Alliance
  gene page

Location &
Maps

• Sequence Map
  Chr9:108518284-110850704 bp

  From MGI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 9, Syntenic
• Mapping Data
  2 experiments

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  17 phenotypes from 1 allele in 2 genetic backgrounds
  3 phenotypes from multigenic genotypes
  11 phenotype references
  

• All Mutations and Alleles
  1
• Spontaneous
  1
• Find Mice (IMSR)
  0 strains or lines available

Homozygotes are deaf, hyperactive, and exhibit circling behavior, reduced rearing behavior, and reduced body weight. Outer hair cells are absent and spiral ganglion cells show severe degeneration. Females exhibit pup cannibalization.

Expression

• Other Vertebrate Links
  Xenbase cir1

Sequences &
Gene Models

• NCBI Gene
  191577

References

• Summaries
  All 12

  Phenotypes 11
• Earliest
  J:73719 Lee JW, et al., Circling mouse: possible animal model for deafness. Comp Med. 2001 Dec;51(6):550-4
• Latest
  J:218768 Lee Y, et al., Vesicular glutamate transporter 3 is strongly upregulated in cochlear inner hair cells and spiral ganglion cells of developing circling mice. Neurosci Lett. 2015 Jan 1;584:320-4