About   Help   FAQ
Znrf1 Gene Detail
Summary
  • Symbol
    Znrf1
  • Name
    zinc and ring finger 1
  • Synonyms
    B830022L21Rik, nin283, Rnf42, Zrfp1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2177308
    NCBI Gene: 170737
  • Alliance
    gene page
  • Transcription Start Sites
    24 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:112262652-112352352 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 57.98 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2357 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2177308
 protein coding gene Chr8:112262652-112352662 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034141
 protein coding gene Chr8:114318435-114426563 (+)
A/J MGP_AJ_G0034121
 protein coding gene Chr8:109676996-109769523 (+)
AKR/J MGP_AKRJ_G0034048
 protein coding gene Chr8:112888021-112980523 (+)
BALB/cJ MGP_BALBcJ_G0034115
 protein coding gene Chr8:109847281-109936664 (+)
C3H/HeJ MGP_C3HHeJ_G0033826
 protein coding gene Chr8:113619014-113713081 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034635
 protein coding gene Chr8:118318812-118416484 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031577
 protein coding gene Chr8:102636813-102726262 (+)
CAST/EiJ MGP_CASTEiJ_G0033153
 protein coding gene Chr8:113243936-113337133 (+)
CBA/J MGP_CBAJ_G0033799
 protein coding gene Chr8:122375968-122480067 (+)
DBA/2J MGP_DBA2J_G0033955
 protein coding gene Chr8:108952550-109042785 (+)
FVB/NJ MGP_FVBNJ_G0033898
 protein coding gene Chr8:107928199-108022143 (+)
LP/J MGP_LPJ_G0034045
 protein coding gene Chr8:114483722-114577311 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033945
 protein coding gene Chr8:125221459-125349468 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034653
 protein coding gene Chr8:112871783-112968479 (+)
PWK/PhJ MGP_PWKPhJ_G0032855
 protein coding gene Chr8:108548014-108639638 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032695
 protein coding gene Chr8:111528081-111620421 (+)
WSB/EiJ MGP_WSBEiJ_G0033269
 protein coding gene Chr8:113551671-113647661 (+)



Homology
more
  • Human Ortholog
    ZNRF1, zinc and ring finger 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZNRF1, zinc and ring finger 1
  • Synonyms
    NIN283
  • Links
    NCBI Gene ID: 84937
    neXtProt AC: NX_Q8ND25
    UniProt: Q8ND25

  • Chr Location
    16q23.1; chr16:74999024-75110994 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    771
  • Tissues
    41
  • cDNA Data
    10
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 170737 NCBI Gene Model | MGI Sequence Detail 89701 C57BL/6J ±  kb
    transcript NM_133206 RefSeq | MGI Sequence Detail 5387 C57BL/6  
    polypeptide Q91V17 UniProt | EBI | MGI Sequence Detail 227 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 11

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1915360, MGI:2142443
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 5
      Gene Ontology 7
      Phenotypes 9
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:335622 Lin YS, et al., The Src-ZNRF1 axis controls TLR3 trafficking and interferon responses to limit lung barrier damage. J Exp Med. 2023 Aug 7;220(8)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory