Vasn MGI Mouse Gene Detail - MGI:2177651

Symbol

Vasn
Name

vasorin
Synonyms

2610528G05Rik, ATIA, Slitl2

Feature Type

protein coding gene
IDs

MGI:2177651
NCBI Gene: 246154
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr16:4457805-4468666 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 2.46 cM, cytoband A1
Mapping Data

2 experiments

SNPs within 2kb

243 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2177651	protein coding gene	Chr16:4457805-4469030 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022468	protein coding gene	Chr16:1142613-1153475 (+)
A/J	MGP_AJ_G0022430	protein coding gene	Chr16:966613-977390 (+)
AKR/J	MGP_AKRJ_G0022407	protein coding gene	Chr16:1155290-1166151 (+)
BALB/cJ	MGP_BALBcJ_G0022435	protein coding gene	Chr16:1120210-1131080 (+)
C3H/HeJ	MGP_C3HHeJ_G0022202	protein coding gene	Chr16:1171902-1182765 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022884	protein coding gene	Chr16:1221709-1232583 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020405	protein coding gene	Chr16:908385-919175 (+)
CAST/EiJ	MGP_CASTEiJ_G0021728	protein coding gene	Chr16:1161188-1171969 (+)
CBA/J	MGP_CBAJ_G0022171	protein coding gene	Chr16:1282408-1293284 (+)
DBA/2J	MGP_DBA2J_G0022302	protein coding gene	Chr16:1078114-1089042 (+)
FVB/NJ	MGP_FVBNJ_G0022277	protein coding gene	Chr16:1062799-1073671 (+)
LP/J	MGP_LPJ_G0022370	protein coding gene	Chr16:1144894-1155952 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022299	protein coding gene	Chr16:1154803-1165671 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022896	protein coding gene	Chr16:1119258-1130132 (+)
PWK/PhJ	MGP_PWKPhJ_G0021468	protein coding gene	Chr16:1138340-1149710 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021299	protein coding gene	Chr16:1208399-1221301 (+)
WSB/EiJ	MGP_WSBEiJ_G0021777	protein coding gene	Chr16:1132245-1143138 (+)

Human Ortholog

VASN, vasorin

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

VASN, vasorin
Synonyms

SLITL2
Links

HGNC:18517

NCBI Gene ID: 114990

neXtProt AC: NX_Q6EMK4

UniProt: Q6EMK4
Chr Location

16p13.3

MGI Vertebrate Homology

Vasn stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: VASN
Gene Tree

Vasn

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Phenotype Summary

9 phenotypes from 1 allele in 1 genetic background
1 phenotype from multigenic genotypes
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Endonuclease-mediated

5
Gene trapped

1
Targeted

5
Incidental Mutations

APF
Find Mice (IMSR)

23 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a targeted allele exhibit increased sensitivity to TNFalpha-induced lethality, TNFalpha-, cycloheximide-, or CoCl2-induced cell death, and reduced male fertility.

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All GO Annotations

21
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

879
Tissues

106
cDNA Data

69
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase vasn

ZFIN vasna

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All Sequences

34
RefSeq

2
UniProt

1
CCDS

CCDS27921.1

Ensembl

ENSMUSG00000039646 (Evidence)
NCBI Gene

246154

			Length	Strain/Species	Flank
genomic	ENSMUSG00000039646	Ensembl Gene Model \| MGI Sequence Detail	10862	C57BL/6J	± kb
transcript	ENSMUST00000038770	Ensembl \| MGI Sequence Detail	2829	Not Applicable
polypeptide	ENSMUSP00000045162	Ensembl \| MGI Sequence Detail	673	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000017262 vasorin

(term hierarchy)
InterPro Domains

IPR000483 Cysteine-rich flanking region, C-terminal

IPR000742 EGF-like domain

IPR003961 Fibronectin type III

IPR036116 Fibronectin type III superfamily

IPR013783 Immunoglobulin-like fold

IPR001611 Leucine-rich repeat

IPR050541 Leucine-rich repeat and transmembrane domain-containing protein

IPR032675 Leucine-rich repeat domain superfamily

IPR000372 Leucine-rich repeat N-terminal domain

IPR003591 Leucine-rich repeat, typical subtype
GlyGen

Q9CZT5 6 sites, 6 N-linked glycans (5 sites)

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All nucleic 71

cDNA 70

Other 1

Microarray probesets 3

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MGI:1921457

Summaries

All 40

Developmental Gene Expression 6

Gene Ontology 4

Phenotypes 10
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:335228 Yang L, et al., Vasorin Deletion in C57BL/6J Mice Induces Hepatocyte Autophagy through Glycogen-Mediated mTOR Regulation. Nutrients. 2022 Aug 31;14(17)

TSS for Vasn:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr136861	Chr16:4457801-4457808 (+)	0 bp
Tssr136862	Chr16:4457820-4457842 (+)	26 bp
Tssr136863	Chr16:4467030-4467044 (+)	9,232 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24