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Tmem259 Gene Detail
Summary
  • Symbol
    Tmem259
  • Name
    transmembrane protein 259
  • Synonyms
    membralin, ORF61
  • Feature Type
    protein coding gene
  • IDs
    MGI:2177957
    NCBI Gene: 216157
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:79812954-79820159 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 39.72 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    182 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2177957
 protein coding gene Chr10:79810782-79820164 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017475
 protein coding gene Chr10:80546313-80557377 (-)
A/J MGP_AJ_G0017453
 protein coding gene Chr10:77731135-77740479 (-)
AKR/J MGP_AKRJ_G0017414
 protein coding gene Chr10:79848638-79857984 (-)
BALB/cJ MGP_BALBcJ_G0017415
 protein coding gene Chr10:77958228-77967847 (-)
C3H/HeJ MGP_C3HHeJ_G0017238
 protein coding gene Chr10:79954722-79964091 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017869
 protein coding gene Chr10:83328192-83341582 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015557
 protein coding gene Chr10:73956731-73966350 (-)
CAST/EiJ MGP_CASTEiJ_G0016805
 protein coding gene Chr10:80150760-80161149 (-)
CBA/J MGP_CBAJ_G0017210
 protein coding gene Chr10:86555708-86568154 (-)
DBA/2J MGP_DBA2J_G0017316
 protein coding gene Chr10:76947567-76957342 (-)
FVB/NJ MGP_FVBNJ_G0017310
 protein coding gene Chr10:76126957-76136342 (-)
LP/J MGP_LPJ_G0017387
 protein coding gene Chr10:81023273-81032437 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017336
 protein coding gene Chr10:88519035-88528399 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017910
 protein coding gene Chr10:79838068-79847442 (-)
PWK/PhJ MGP_PWKPhJ_G0016586
 protein coding gene Chr10:76813707-76823529 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016375
 protein coding gene Chr10:78808811-78819255 (-)
WSB/EiJ MGP_WSBEiJ_G0016865
 protein coding gene Chr10:79860749-79872880 (-)



Homology
more
  • Human Ortholog
    TMEM259, transmembrane protein 259
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TMEM259, transmembrane protein 259
  • Synonyms
    ASBABP1, C19orf6, MBRL, MEMBRALIN, R32184_3
  • Links
    NCBI Gene ID: 91304
    neXtProt AC: NX_Q4ZIN3
    UniProt: Q4ZIN3

  • Chr Location
    19p13.3; chr19:1009648-1021179 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    15 phenotype references
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    1
  • Gene trapped
    2
  • Targeted
    3
  • Transgenic
    1
  • Genomic Mutations
    2 involving Tmem259
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    19 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    100
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 216157 NCBI Gene Model | MGI Sequence Detail 7206 C57BL/6J ±  kb
transcript NM_001359632 RefSeq | MGI Sequence Detail 2242 C57BL/6  
polypeptide Q8CIV2 UniProt | EBI | MGI Sequence Detail 574 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 101
    Genomic 1
    cDNA 100

    Microarray probesets 4
Other
Accession IDs
less
MGI:2158302
References
more
  • Summaries
    All 36
    Gene Ontology 3
    Phenotypes 15
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:280912 Jiang LL, et al., Membralin deficiency dysregulates astrocytic glutamate homeostasis leading to ALS-like impairment. J Clin Invest. 2019 May 21;129(8):3103-3120
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory