Ts(17¹⁶)65Dn Cytogenetic Marker Detail

Summary

• Symbol
  Ts(17¹⁶)65Dn
• Name
  trisomy, Chr 16 translocation to Chr 17, Davisson 65
• Synonyms
  trisomy 16, Ts65Dn

• Feature Type
  chromosomal translocation
• IDs
  MGI:2178111

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 16, Syntenic
• Mapping Data
  1 experiment

Human Diseases

• Diseases
  1 with Ts(17<16>)65Dn mouse models

Human Disease

Mouse Models

Down syndrome

IDs

Down syndrome      

DOID:14250
ICD10CM:Q90
ICD9CM:758.0
MESH:D004314
NCI:C2993
OMIM:190685
ORDO:870
UMLS_CUI:C0013080

View 5 models

Mouse Models

Human Disease Modeled: Down syndrome

Allelic Composition	Genetic Background	Reference	Phenotypes
Ts(1716)65Dn/0	B6EiC3Sn a/A-Ts(17^16)65Dn/J	J:170195	View
Ts(1716)65Dn/0	B6EiC3Sn.BLiA-Ts(17^16)65Dn/DnJ	J:153579	View
Ts(1716)65Dn/0	involves: BALB/c * C3H/He * C57BL/6JEiJ * DBA/2J	J:331897	View
Ts(1716)65Dn/0	involves: C3H/HeJ * C57BL/6J * DBA/2J	J:174270	View
Ts(1716)65Dn/0	involves: C3H/HeSnJ * C57BL/6JEi * DBA/2J	J:94569 J:96650	View

Click on a disease name to see all genes associated with that disease.

• Mutations/Alleles
  1 with disease annotations

• References
  6 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  69 phenotypes from 1 allele in 10 genetic backgrounds
  5 phenotypes from multigenic genotypes
  1 images
  348 phenotype references
  

• All Mutations and Alleles
  1
• Radiation induced
  1
• Find Mice (IMSR)
  2 strains or lines available

References

• Summaries
  All 350

  Diseases 6

  Phenotypes 348
• Earliest
  J:30229 Davisson MT, et al., Segmental trisomy as a mouse model for Down syndrome. Prog Clin Biol Res. 1993;384:117-33
• Latest
  J:354984 Emili M, et al., Reversal of neurodevelopmental impairment and cognitive enhancement by pharmacological intervention with the polyphenol polydatin in a Down syndrome model. Neuropharmacology. 2024 Sep 27;261:110170