Stab2 MGI Mouse Gene Detail - MGI:2178743

Symbol

Stab2
Name

stabilin 2
Synonyms

FEEL-2, STAB-2

Feature Type

protein coding gene
IDs

MGI:2178743
NCBI Gene: 192188
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr10:86677062-86843889 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 43.14 cM
Mapping Data

2 experiments

SNPs within 2kb

5035 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2178743	protein coding gene	Chr10:86677058-86843902 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0017616	protein coding gene	Chr10:87821574-87997647 (-)
A/J	MGP_AJ_G0017595	protein coding gene	Chr10:84916398-85094539 (-)
AKR/J	MGP_AKRJ_G0017553	protein coding gene	Chr10:87304373-87475376 (-)
BALB/cJ	MGP_BALBcJ_G0017558	protein coding gene	Chr10:85179089-85352005 (-)
C3H/HeJ	MGP_C3HHeJ_G0017381	protein coding gene	Chr10:87300192-87474265 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0018015	protein coding gene	Chr10:90797939-90984877 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015697	protein coding gene	Chr10:80718107-80888063 (-)
CAST/EiJ	MGP_CASTEiJ_G0016946	protein coding gene	Chr10:87196275-87375085 (-)
CBA/J	MGP_CBAJ_G0017350	protein coding gene	Chr10:94566138-94759239 (-)
DBA/2J	MGP_DBA2J_G0017456	protein coding gene	Chr10:84019994-84192113 (-)
FVB/NJ	MGP_FVBNJ_G0017448	protein coding gene	Chr10:83291474-83463525 (-)
LP/J	MGP_LPJ_G0017530	protein coding gene	Chr10:88517426-88710170 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017479	protein coding gene	Chr10:96132271-96314726 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018052	protein coding gene	Chr10:87148422-87319917 (-)
PWK/PhJ	MGP_PWKPhJ_G0016727	protein coding gene	Chr10:84033926-84209563 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0016515	protein coding gene	Chr10:85875900-86043957 (-)
WSB/EiJ	MGP_WSBEiJ_G0017005	protein coding gene	Chr10:87114741-87289379 (-)

Human Ortholog

STAB2, stabilin 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

STAB2, stabilin 2
Synonyms

FEEL2, FELE-2, FELL2, FEX2, HARE, SCARH1
Links

HGNC:18629

NCBI Gene ID: 55576

neXtProt AC: NX_Q8WWQ8

UniProt: Q8WWQ8
Chr Location

12q23.3; chr12:103587273-103766719 (+) GRCh38

MGI Vertebrate Homology

Stab2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: STAB2
Gene Tree

Stab2

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Phenotype Summary

4 phenotypes from 2 alleles in 3 genetic backgrounds
12 phenotypes from multigenic genotypes
2 images
22 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Chemically induced (other)

1
Endonuclease-mediated

5
Gene trapped

1
Targeted

5
Transgenic

4
Genomic Mutations

1 involving Stab2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

138 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Mice homozygous for knock-out alleles exhibit no gross abnormaities. Mice homozygous for one null allele display elevated serum hyaluronic acid levels and decreased metastasis.

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All GO Annotations

25
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

775
Tissues

42
cDNA Data

18
Literature Summary

10

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase stab2

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All Sequences

72
RefSeq

16
UniProt

12
CCDS

CCDS36021.1

Ensembl

ENSMUSG00000035459 (Evidence)
NCBI Gene

192188

			Length	Strain/Species	Flank
genomic	ENSMUSG00000035459	Ensembl Gene Model \| MGI Sequence Detail	166828	C57BL/6J	± kb
transcript	ENSMUST00000035288	Ensembl \| MGI Sequence Detail	8228	Not Applicable
polypeptide	ENSMUSP00000048309	Ensembl \| MGI Sequence Detail	2559	Not Applicable

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UniProt

12 Sequences
Protein Ontology

PR:000015702 stabilin-2

(term hierarchy)
InterPro Domains

IPR016187 C-type lectin fold

IPR016186 C-type lectin-like/link domain superfamily

IPR024731 EGF domain

IPR001881 EGF-like calcium-binding domain

IPR000742 EGF-like domain

IPR000782 FAS1 domain

IPR036378 FAS1 domain superfamily

IPR009030 Growth factor receptor cysteine-rich domain superfamily

IPR002049 Laminin-type EGF domain

IPR000538 Link domain

IPR051146 Phosphatidylserine Receptors and Protein Disulfide Isomerases
GlyGen

Q8R4U0 31 sites, 1 O-linked glycan (2 sites)

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All nucleic 19

cDNA 18

Primer pair 1

Microarray probesets 3

Summaries

All 61

Developmental Gene Expression 10

Gene Ontology 7

Phenotypes 22
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:354240 Krzistetzko J, et al., Association of Differentially Altered Liver Fibrosis with Deposition of TGFBi in Stabilin-Deficient Mice. Int J Mol Sci. 2023 Jun 30;24(13)

TSS for Stab2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr98799	Chr10:86843879-86843895 (-)	2 bp
Tssr98798	Chr10:86843786-86843814 (-)	89 bp
Tssr98797	Chr10:86721705-86721716 (-)	122,178 bp
Tssr98796	Chr10:86721677-86721696 (-)	122,202 bp
Tssr98795	Chr10:86721644-86721667 (-)	122,233 bp
Tssr98794	Chr10:86721610-86721632 (-)	122,268 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24