Tg(GFAP-cre)25Mes
Transgene Detail

Summary

• Symbol: Tg(GFAP-cre)25Mes
• Name: transgene insertion 25, Albee Messing
• MGI ID: MGI:2179048
• Synonyms: Gfa2-Cre, GFAP-Cre, GFAP-Cre-m, hGFAP-cre, hGFAPcre, hGFAP::Cre, Tg95.2, TgN25Mes, TgN(GFAPcre)25Mes
• Transgene: Tg(GFAP-cre)25Mes Location: unknown
• Alliance: Tg(GFAP-cre)25Mes page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(GFAP-cre)25Mes expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  human

  GFAP (2670)

  Gfap	(MGI:95697)

• Mutation details: This transgene expresses Cre recombinase under the control of a human glial fibrillary acidic protein (GFAP) promoter. Cre-mediated recombination occurs primarily in the central nervous system, affecting astrocytes, oligodendroglia, ependyma and some neurons. Expression activity is also present in periportal cells of the liver. Developmental onset of transgene expression occurs in the dorsal and medial regions of the telencephalon by embryonic day 13.5. In adult cerebellum, only astrocytes are immunoreactive for GFAP or Cre recombinase. (J:72509)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	GFAP (human) Summary of all recombinase alleles driven by GFAP. Comparative matrix view of recombinase activities Alliance human GFAP gene page

Disease models

Expression

In Mice Carrying this Mutation:

28 assay results 11 RNA-Seq or microarray experiment(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(GFAP-cre)25Mes

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

Notes

Hemizygous transgenic mice are viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities. Mice that are homozygous for the transgene are not viable.

References

• Original: J:72509 Zhuo L, et al., hGFAP-cre transgenic mice for manipulation of glial and neuronal function in vivo. Genesis. 2001 Oct;31(2):85-94
• All: 421 reference(s)