Tg(Camk2a-tTA)1Mmay
Transgene Detail

Summary

• Symbol: Tg(Camk2a-tTA)1Mmay
• Name: transgene insertion 1, Mark Mayford
• MGI ID: MGI:2179066
• Synonyms: CamDAT, CaMKIIalpha-tTA, CaMKII-tTA, CAMK-rTA, line B, pCaMKII-tTA, Tg^{alpha-CaMkII-tTA}, Tg^{(CaMKIItTA)Mmay}
• Transgene: Tg(Camk2a-tTA)1Mmay Location: Chr12:116064774-116572891 bp Genetic Position: Chr12, Syntenic
• Alliance: Tg(Camk2a-tTA)1Mmay page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Null/knockout, Transactivator)
• Mutations: Insertion, Intergenic deletion, Intragenic deletion
• Mutation details: The transgene contains the tetracycline-controlled transactivator protein (tTA) under regulatory control of the forebrain specific calcium/calmodulin-dependent kinase II promoter. The transgene integrated into chromosome 12 causing a 508.12 Kb deletion and disrupting the following genes: Vipr2, Wdr60, Esyt2, Ncapg2, and Ptprn2. The deletion results in a functional knock-out of Vipr2, Wdr60, Esyt2, and Ncapg2 in homozygous mice. Founder line 1 has a copy number of greater than 20. (J:37107)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 8 strains available Cell Lines: 0 lines available

Notes

This transgene is line B.

Transgenic mice are viable, fertile, and display no overt phenotypic defects. Administration of tetracycline analogs such as doxycycline blocks transgene expression.

References

• Original: J:37107 Mayford M, et al., Control of memory formation through regulated expression of a CaMKII transgene. Science. 1996 Dec 6;274(5293):1678-83
• All: 469 reference(s)