Rttn MGI Mouse Gene Detail - MGI:2179288

Symbol

Rttn
Name

rotatin
Synonyms

4921538A15Rik, C530033I08Rik

Feature Type

protein coding gene
IDs

MGI:2179288
NCBI Gene: 246102
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr18:88989914-89149140 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 58.93 cM
Mapping Data

3 experiments

SNPs within 2kb

3112 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2179288	protein coding gene	Chr18:88989860-89149140 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024616	protein coding gene	Chr18:90315312-90491891 (+)
A/J	MGP_AJ_G0024583	protein coding gene	Chr18:86285314-86447092 (+)
AKR/J	MGP_AKRJ_G0024554	protein coding gene	Chr18:88886752-89053070 (+)
BALB/cJ	MGP_BALBcJ_G0024581	protein coding gene	Chr18:86560523-86723889 (+)
C3H/HeJ	MGP_C3HHeJ_G0024350	protein coding gene	Chr18:89029148-89198645 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025029	protein coding gene	Chr18:92618930-92795463 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022459	protein coding gene	Chr18:85029646-85179643 (+)
CAST/EiJ	MGP_CASTEiJ_G0023822	protein coding gene	Chr18:89498236-89683022 (+)
CBA/J	MGP_CBAJ_G0024320	protein coding gene	Chr18:95914769-96094349 (+)
DBA/2J	MGP_DBA2J_G0024449	protein coding gene	Chr18:85842003-86007073 (+)
FVB/NJ	MGP_FVBNJ_G0024416	protein coding gene	Chr18:85164528-85322640 (+)
LP/J	MGP_LPJ_G0024534	protein coding gene	Chr18:90187517-90350752 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024446	protein coding gene	Chr18:97744432-97952498 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025077	protein coding gene	Chr18:89174400-89344630 (+)
PWK/PhJ	MGP_PWKPhJ_G0023568	protein coding gene	Chr18:86202411-86373177 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023375	protein coding gene	Chr18:89152118-89334304 (+)
WSB/EiJ	MGP_WSBEiJ_G0023885	protein coding gene	Chr18:89079793-89259493 (+)

Human Ortholog

RTTN, rotatin

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RTTN, rotatin
Synonyms

MSSP
Links

HGNC:18654

NCBI Gene ID: 25914

neXtProt AC: NX_Q86VV8

UniProt: Q86VV8
Chr Location

18q22.2; chr18:70003031-70205726 (-) GRCh38

MGI Vertebrate Homology

Rttn stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RTTN
Gene Tree

Rttn

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Phenotype Summary

20 phenotypes from 2 alleles in 2 genetic backgrounds
1 phenotype from multigenic genotypes
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Endonuclease-mediated

1
Gene trapped

10
Spontaneous

1
Targeted

2
Transgenic

1
Genomic Mutations

1 involving Rttn
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

99 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for an insertional mutation exhibit embryonic lethality and neurulation defects resulting in the arrest of gastrulation movements and abnormal left-right specification in the heart.

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All GO Annotations

15
GO References

6

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

762
Tissues

30
cDNA Data

31
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rttn

ZFIN rttn

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All Sequences

65
RefSeq

14
UniProt

4
CCDS

CCDS29390.1

Ensembl

ENSMUSG00000023066 (Evidence)
NCBI Gene

246102

			Length	Strain/Species	Flank
genomic	ENSMUSG00000023066	Ensembl Gene Model \| MGI Sequence Detail	159227	C57BL/6J	± kb
transcript	ENSMUST00000023828	Ensembl \| MGI Sequence Detail	7271	Not Applicable
polypeptide	ENSMUSP00000023828	Ensembl \| MGI Sequence Detail	2226	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000014357 rotatin

(term hierarchy)
InterPro Domains

IPR011989 Armadillo-like helical

IPR016024 Armadillo-type fold

IPR030791 Rotatin

IPR029249 Rotatin, N-terminal
GlyGen

Q8R4Y8 3 sites, 3 N-linked glycans (3 sites)

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All nucleic 34

cDNA 31

Primer pair 1

Other 2

Microarray probesets 5

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MGI:1918209, MGI:2147258, MGI:2441910

Summaries

All 38

Developmental Gene Expression 2

Gene Ontology 6

Phenotypes 12
Earliest

J:45709 Melloy PG, et al., No turning, a mouse mutation causing left-right and axial patterning defects. Dev Biol. 1998 Jan 1;193(1):77-89
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Rttn:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr152267	Chr18:89012731-89012732 (+)	22,818 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24