Oxr1 Gene Detail

Summary

• Symbol
  Oxr1
• Name
  oxidation resistance 1
• Synonyms
  2210416C20Rik, C7, C7B

• Feature Type
  protein coding gene
• IDs
  MGI:2179326
  NCBI Gene: 170719
• Alliance
  gene page
• Transcription Start Sites
  32 TSS

Location &
Maps

• Sequence Map
  Chr15:41310878-41724444 bp, + strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 15, 16.06 cM, cytoband D1
• Mapping Data
  3 experiments

Strain
Comparison

• SNPs within 2kb
  13464 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2179326	protein coding gene	Chr15:41310745-41724447 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021821	protein coding gene	Chr15:39957544-40413233 (+)
A/J	MGP_AJ_G0021781	protein coding gene	Chr15:38416827-38842622 (+)
AKR/J	MGP_AKRJ_G0021762	protein coding gene	Chr15:39589805-40031721 (+)
BALB/cJ	MGP_BALBcJ_G0021788	protein coding gene	Chr15:38504095-38931217 (+)
C3H/HeJ	MGP_C3HHeJ_G0021562	protein coding gene	Chr15:39499014-39921322 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022227	protein coding gene	Chr15:41503525-41960102 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019764	protein coding gene	Chr15:36106807-36514673 (+)
CAST/EiJ	MGP_CASTEiJ_G0021079	protein coding gene	Chr15:39983016-40423382 (+)
CBA/J	MGP_CBAJ_G0021531	protein coding gene	Chr15:42934221-43413993 (+)
DBA/2J	MGP_DBA2J_G0021655	protein coding gene	Chr15:38263195-38686926 (+)
FVB/NJ	MGP_FVBNJ_G0021633	protein coding gene	Chr15:37602988-38016569 (+)
LP/J	MGP_LPJ_G0021725	protein coding gene	Chr15:39769633-40218280 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021657	protein coding gene	Chr15:45977393-46453360 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022250	protein coding gene	Chr15:39763989-40201349 (+)
PWK/PhJ	MGP_PWKPhJ_G0020824	protein coding gene	Chr15:38304442-38731579 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020661	protein coding gene	Chr15:39384953-39846840 (+)
WSB/EiJ	MGP_WSBEiJ_G0021134	protein coding gene	Chr15:39663257-40108670 (+)

Homology

• Human Ortholog
  OXR1, oxidation resistance 1

• Vertebrate Orthologs
  4

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  OXR1, oxidation resistance 1
  
• Synonyms
  CHEGDD, Nbla00307, TLDC3
• Links
  HGNC:15822

  NCBI Gene ID: 55074

  neXtProt AC: NX_Q8N573

  UniProt: Q8N573

  
  
• Chr Location
  8q23.1; chr8:106270144-106752694 (+)  GRCh38

---

• MGI Vertebrate Homology
  Oxr1 stringent orthology
  1 human;1 mouse;1 rat;2 zebrafish
  
• HCOP
  vertebrate homology predictions: OXR1
• Gene Tree
  Oxr1
  

Human Diseases

• Diseases
  1 with human OXR1 associations

				Human Disease	Mouse Models
				cerebellar hyplasia/atrophy, epilepsy, and global developmental delay IDs cerebellar hyplasia/atrophy, epilepsy, and global developmental delay       DOID:0070339 OMIM:213000 ORDO:2246

Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  8 phenotypes from 2 alleles in 3 genetic backgrounds
  6 phenotypes from multigenic genotypes
  1 images
  24 phenotype references
  

• All Mutations and Alleles
  51
• Chemically induced (other)
  2
• Endonuclease-mediated
  1
• Gene trapped
  40
• Spontaneous
  1
• Targeted
  6
• Transgenic
  1
• Genomic Mutations
  3 involving Oxr1
• Incidental Mutations
  Mutagenetix , APF
• Find Mice (IMSR)
  37 strains or lines available
• Comparison Matrix
  Gene Expression + Phenotype
• Recombinase Activity
  Comparison Matrix Gene Expression + Recombinase Activity

Homozygous mutation of this gene results in progressive cerebellar neurodegeneration and ataxia, increased apoptosis in the cerebellar granule cell layer, and premature death.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  13
• GO References
  5

Expression

• Assay Results
  740
• Tissues
  17
• cDNA Data
  10
• Literature Summary
  6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase oxr1
  ZFIN oxr1a, oxr1b

Sequences &
Gene Models

• All Sequences
  113
• RefSeq
  37
• UniProt
  11
• CCDS
  CCDS27448.1, CCDS49598.1, CCDS49599.1, CCDS49600.1, CCDS49601.1, CCDS88760.1

• Ensembl
  ENSMUSG00000022307 (Evidence)
• NCBI Gene
  170719

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000022307	Ensembl Gene Model | MGI Sequence Detail	413567	C57BL/6J
transcript	ENSMUST00000110297	Ensembl | MGI Sequence Detail	4599	Not Applicable
polypeptide	ENSMUSP00000105926	Ensembl | MGI Sequence Detail	866	Not Applicable

Protein
Information

• UniProt
  11 Sequences
• Protein Ontology
  PR:000012097 oxidation resistance protein 1
  (term hierarchy)
• InterPro Domains
  IPR018392 LysM domain
  IPR036779 LysM domain superfamily
  IPR006571 TLDc domain
• GlyGen
  Q4KMM3 6 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (4 sites)

Molecular
Reagents

• All nucleic 15

  cDNA 12

  Primer pair 2

  Other 1

  
  

  Microarray probesets 5

Other
Accession IDs

MGI:1922080

References

• Summaries
  All 54

  Developmental Gene Expression 6

  Gene Ontology 5

  Phenotypes 24
• Earliest
  J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
• Latest
  J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Oxr1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr131187	Chr15:41310219-41310231 (+)	-653 bp
Tssr131188	Chr15:41310697-41310704 (+)	-177 bp
Tssr131189	Chr15:41310743-41310749 (+)	-132 bp
Tssr131190	Chr15:41310755-41310765 (+)	-118 bp
Tssr131191	Chr15:41310779-41310810 (+)	-83 bp
Tssr131192	Chr15:41310815-41310827 (+)	-57 bp
Tssr131193	Chr15:41310834-41310875 (+)	-23 bp
Tssr131194	Chr15:41310887-41310905 (+)	18 bp
Tssr131195	Chr15:41310916-41310935 (+)	48 bp
Tssr131196	Chr15:41350755-41350758 (+)	39,879 bp
Tssr4587	Chr15:41368378-41368380 (+)	57,501 bp
Tssr131197	Chr15:41375017-41375018 (+)	64,140 bp
Tssr131198	Chr15:41466711-41466724 (+)	155,840 bp
Tssr131199	Chr15:41475972-41475983 (+)	165,100 bp
Tssr131200	Chr15:41573995-41574048 (+)	263,144 bp
Tssr131201	Chr15:41574050-41574057 (+)	263,176 bp
Tssr4588	Chr15:41614880-41614891 (+)	304,008 bp
Tssr131202	Chr15:41614900-41614928 (+)	304,036 bp
Tssr131203	Chr15:41615050-41615079 (+)	304,187 bp
Tssr131204	Chr15:41615087-41615097 (+)	304,214 bp
Tssr131205	Chr15:41652162-41652174 (+)	341,290 bp
Tssr131206	Chr15:41652330-41652373 (+)	341,474 bp
Tssr131207	Chr15:41652375-41652384 (+)	341,502 bp
Tssr131208	Chr15:41652393-41652409 (+)	341,523 bp
Tssr131209	Chr15:41652891-41652923 (+)	342,029 bp
Tssr131210	Chr15:41657880-41657885 (+)	347,005 bp
Tssr131211	Chr15:41683516-41683538 (+)	372,649 bp
Tssr4589	Chr15:41696851-41696855 (+)	385,975 bp
Tssr131214	Chr15:41698510-41698521 (+)	387,638 bp
Tssr131215	Chr15:41711392-41711396 (+)	400,516 bp
Tssr131216	Chr15:41712359-41712362 (+)	401,483 bp
Tssr131217	Chr15:41723328-41723340 (+)	412,456 bp