Mvd MGI Mouse Gene Detail - MGI:2179327 - mevalonate (diphospho) decarboxylase

Symbol

Mvd
Name

mevalonate (diphospho) decarboxylase

Feature Type

protein coding gene
IDs

MGI:2179327
NCBI Gene: 192156
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr8:123160340-123170161 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 71.05 cM
Mapping Data

2 experiments

SNPs within 2kb

367 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2179327	protein coding gene	Chr8:123160335-123170161 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0034225	protein coding gene	Chr8:125970778-125980583 (-)
A/J	MGP_AJ_G0034205	protein coding gene	Chr8:120757339-120768252 (-)
AKR/J	MGP_AKRJ_G0034132	protein coding gene	Chr8:124275645-124287076 (-)
BALB/cJ	MGP_BALBcJ_G0034199	protein coding gene	Chr8:120959032-120969532 (-)
C3H/HeJ	MGP_C3HHeJ_G0033910	protein coding gene	Chr8:124975215-124985041 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0034719	protein coding gene	Chr8:130155835-130185654 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031661	protein coding gene	Chr8:113593076-113602815 (-)
CAST/EiJ	MGP_CASTEiJ_G0033237	protein coding gene	Chr8:125053792-125065473 (-)
CBA/J	MGP_CBAJ_G0033883	protein coding gene	Chr8:134960464-134972165 (-)
DBA/2J	MGP_DBA2J_G0034039	protein coding gene	Chr8:119949455-119959281 (-)
FVB/NJ	MGP_FVBNJ_G0033982	protein coding gene	Chr8:119087483-119102332 (-)
LP/J	MGP_LPJ_G0034128	protein coding gene	Chr8:126097877-126109747 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034029	protein coding gene	Chr8:137138121-137150806 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034737	protein coding gene	Chr8:124459924-124469750 (-)
PWK/PhJ	MGP_PWKPhJ_G0032939	protein coding gene	Chr8:119769048-119779192 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0032779	protein coding gene	Chr8:123184393-123195735 (-)
WSB/EiJ	MGP_WSBEiJ_G0033353	protein coding gene	Chr8:125214950-125224778 (-)

Human Ortholog

MVD, mevalonate diphosphate decarboxylase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MVD, mevalonate diphosphate decarboxylase
Synonyms

FP17780, MDDase, MPD, POROK7
Links

HGNC:7529

NCBI Gene ID: 4597

neXtProt AC: NX_P53602

UniProt: P53602
Chr Location

16q24.2; chr16:88651935-88663161 (-) GRCh38

MGI Vertebrate Homology

Mvd stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MVD
Protein SuperFamily

Mev_P_decrbx
Gene Tree

Mvd

Diseases

1 with human MVD associations

				Human Disease	Mouse Models
				porokeratosis IDs porokeratosis DOID:3805 DOID:8668 ICD10CM:L56.5 ICD9CM:692.75 MESH:D017499 NCI:C85019 OMIM:175800 UMLS_CUI:C0162839 UMLS_CUI:C0265970

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Endonuclease-mediated

3
Gene trapped

4
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

23 strains or lines available

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All GO Annotations

22
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

60
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mvd

ZFIN mvda

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All Sequences

47
RefSeq

3
UniProt

3
CCDS

CCDS22738.1

Ensembl

ENSMUSG00000006517 (Evidence)
NCBI Gene

192156

			Length	Strain/Species	Flank
genomic	ENSMUSG00000006517	Ensembl Gene Model \| MGI Sequence Detail	9822	C57BL/6J	± kb
transcript	ENSMUST00000006692	Ensembl \| MGI Sequence Detail	1756	Not Applicable
polypeptide	ENSMUSP00000006692	Ensembl \| MGI Sequence Detail	401	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000010785 diphosphomevalonate decarboxylase

(term hierarchy)
PDB

3F0N
EC

4.1.1.33
InterPro Domains

IPR029765 Diphosphomevalonate decarboxylase

IPR005935 Diphosphomevalonate/phosphomevalonate decarboxylase

IPR036554 GHMP kinase, C-terminal domain superfamily

IPR041431 Mvd1, C-terminal

IPR020568 Ribosomal protein uS5 domain 2-type superfamily

IPR014721 Small ribosomal subunit protein uS5 domain 2-type fold, subgroup

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All nucleic 61

cDNA 60

Primer pair 1

Microarray probesets 5

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MGI:2142855

Summaries

All 43

Developmental Gene Expression 1

Gene Ontology 10

Phenotypes 10
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Mvd:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr83271	Chr8:123170171-123170178 (-)	-14 bp
Tssr83270	Chr8:123170143-123170165 (-)	7 bp
Tssr83269	Chr8:123170102-123170142 (-)	39 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24