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Mill2 Gene Detail
Summary
  • Symbol
    Mill2
  • Name
    MHC I like leukocyte 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2179989
    NCBI Gene: 243864
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:18573891-18599327 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 9.35 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1008 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2179989
 protein coding gene Chr7:18573878-18603621 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031745
 protein coding gene Chr7:16759423-16789070 (+)
A/J MGP_AJ_G0031721
 protein coding gene Chr7:16478700-16501563 (+)
AKR/J MGP_AKRJ_G0031647
 protein coding gene Chr7:16925416-16948965 (+)
BALB/cJ MGP_BALBcJ_G0031726
 protein coding gene Chr7:16660950-16683904 (+)
C3H/HeJ MGP_C3HHeJ_G0031448
 protein coding gene Chr7:17167006-17192109 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032192
 protein coding gene Chr7:17647366-17678486 (+)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0030791
 protein coding gene Chr7:13577514-13605093 (+)
CBA/J MGP_CBAJ_G0031410
 protein coding gene Chr7:18269033-18294094 (+)
DBA/2J MGP_DBA2J_G0031565
 protein coding gene Chr7:16413464-16438825 (+)
FVB/NJ MGP_FVBNJ_G0031517
 protein coding gene Chr7:16261923-16291891 (+)
LP/J MGP_LPJ_G0031648
 protein coding gene Chr7:17122799-17145317 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031553
 protein coding gene Chr7:18155742-18181277 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032220
 protein coding gene Chr7:16522392-16552991 (+)
PWK/PhJ MGP_PWKPhJ_G0030515
 protein coding gene Chr7:13491017-13516803 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030342
 protein coding gene Chr7:11202627-11227233 (+)
WSB/EiJ MGP_WSBEiJ_G0030891
 protein coding gene Chr7:16717120-16745168 (+)



Homology
more
  • Human Ortholog
    MICA, MHC class I polypeptide-related sequence A
  • Vertebrate Orthologs
    6
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MICA, MHC class I polypeptide-related sequence A
  • Synonyms
    MIC-A, PERB11.1
  • Links
    NCBI Gene ID: 100507436
    neXtProt AC: NX_Q29983
    UniProt: Q29983

  • Chr Location
    chr6:31399784-31415315 (+)  GRCh38
  • Human Ortholog
    MICB, MHC class I polypeptide-related sequence B
  • Synonyms
    PERB11.2
  • Links
    NCBI Gene ID: 4277
    neXtProt AC: NX_Q29980
    UniProt: Q29980

  • Chr Location
    6p21.33; chr6:31494881-31511124 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    5
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000040987 Ensembl Gene Model | MGI Sequence Detail 25437 C57BL/6J ±  kb
transcript ENSMUST00000228493 Ensembl | MGI Sequence Detail 2043 Not Applicable  
polypeptide ENSMUSP00000154268 Ensembl | MGI Sequence Detail 355 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • PDB
    6A97
  • InterPro Domains
    IPR050208 Antigen-presenting and immune regulatory MHC class I-related
    IPR003597 Immunoglobulin C1-set
    IPR007110 Immunoglobulin-like domain
    IPR036179 Immunoglobulin-like domain superfamily
    IPR013783 Immunoglobulin-like fold
    IPR011162 MHC classes I/II-like antigen recognition protein
    IPR001039 MHC class I alpha chain, alpha1 alpha2 domains
    IPR011161 MHC class I-like antigen recognition-like
    IPR037055 MHC class I-like antigen recognition-like superfamily
  • GlyGen
    Q8HWE5 3 sites, 1 N-linked glycan (2 sites)
Molecular
Reagents
less
  • All nucleic 5
    cDNA 5

    Microarray probesets 1
References
more
  • Summaries
    All 19
    Gene Ontology 3
    Phenotypes 3
  • Earliest
    J:79325 Kasahara M, et al., A family of MHC class I-like genes located in the vicinity of the mouse leukocyte receptor complex. Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13687-92
  • Latest
    J:268516 Kajikawa M, et al., Structure of MHC class I-like MILL2 reveals heparan-sulfate binding and interdomain flexibility. Nat Commun. 2018 Oct 18;9(1):4330
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory