About   Help   FAQ
Lgi4 Gene Detail
Summary
  • Symbol
    Lgi4
  • Name
    leucine-rich repeat LGI family, member 4
  • Synonyms
    clp
  • Feature Type
    protein coding gene
  • IDs
    MGI:2180197
    NCBI Gene: 243914
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:30758767-30770360 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 19.29 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    393 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2180197
 protein coding gene Chr7:30758360-30770360 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032059
 protein coding gene Chr7:30119478-30131139 (+)
A/J MGP_AJ_G0032036
 protein coding gene Chr7:29308147-29319631 (+)
AKR/J MGP_AKRJ_G0031969
 protein coding gene Chr7:30044230-30055838 (+)
BALB/cJ MGP_BALBcJ_G0032043
 protein coding gene Chr7:29483132-29494607 (+)
C3H/HeJ MGP_C3HHeJ_G0031760
 protein coding gene Chr7:30508460-30520028 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032509
 protein coding gene Chr7:31127421-31139026 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029559
 protein coding gene Chr7:30261551-30272899 (+)
CAST/EiJ MGP_CASTEiJ_G0031096
 protein coding gene Chr7:23754885-23770751 (+)
CBA/J MGP_CBAJ_G0031728
 protein coding gene Chr7:32587787-32599361 (+)
DBA/2J MGP_DBA2J_G0031880
 protein coding gene Chr7:29022461-29034085 (+)
FVB/NJ MGP_FVBNJ_G0031836
 protein coding gene Chr7:29141591-29153199 (+)
LP/J MGP_LPJ_G0031961
 protein coding gene Chr7:30458128-30469835 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031873
 protein coding gene Chr7:31811501-31822976 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032535
 protein coding gene Chr7:29556757-29568383 (+)
PWK/PhJ MGP_PWKPhJ_G0030818
 protein coding gene Chr7:24057110-24069013 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030655
 protein coding gene Chr7:20547495-20558948 (+)
WSB/EiJ MGP_WSBEiJ_G0031206
 protein coding gene Chr7:29962950-29975408 (+)



Homology
more
  • Human Ortholog
    LGI4, leucine rich repeat LGI family member 4
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LGI4, leucine rich repeat LGI family member 4
  • Synonyms
    AMC1, AMCNMY, LGIL3
  • Links
    NCBI Gene ID: 163175
    neXtProt AC: NX_Q8N135
    UniProt: Q8N135

  • Chr Location
    19q13.12; chr19:35124513-35142451 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human LGI4 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    35 phenotypes from 4 alleles in 7 genetic backgrounds
    7 phenotypes from multigenic genotypes
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant animals have an abnormal posture where the forelimbs are flexed and rotated inwards. The peripheral nervous system is delayed in myelination.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    812
  • Tissues
    48
  • cDNA Data
    11
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000036560 Ensembl Gene Model | MGI Sequence Detail 11594 C57BL/6J ±  kb
    transcript ENSMUST00000039775 Ensembl | MGI Sequence Detail 4037 Not Applicable  
    polypeptide ENSMUSP00000041579 Ensembl | MGI Sequence Detail 537 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 11

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-2019, MGI:88420
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 6
      Gene Ontology 10
      Phenotypes 19
    • Earliest
      J:11392 Henry EW, et al., The mouse mutation claw paw: forelimb deformity and delayed myelination throughout the peripheral nervous system. J Hered. 1991 Jul-Aug;82(4):287-94
    • Latest
      J:345844 Guo Y, et al., Docking protein 6 (DOK6) selectively docks the neurotrophic signaling transduction to restrain peripheral neuropathy. Signal Transduct Target Ther. 2024 Feb 14;9(1):32
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory