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Zar1 Gene Detail
Summary
  • Symbol
    Zar1
  • Name
    zygote arrest 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2180337
    NCBI Gene: 317755
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr5:72734457-72738427 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Per David Webb This Slc10a4> Zar1>duplication appears to be restricted to M. musculus and M. caroli. I couldn't find a similar duplication in other Mus assemblies (eg, M. pahari, M. spicilegus...) or in the assemblies of Peromyscus maniculatus, beaver or human. The gene order in M. musculus and M. caroli is: Nfxl1< loc> Zar1< Slc10a4ps< Cnga1< Nipal1> Txk< Tec< Slain2> Slc10a4> Zar1ps> Fryl< whereas the following gene order is strongly conserved in all other gnathostomes except teleosts: NFXL1< CNGA1< NIPAL1> TXK< TEC< SLAIN2> SLC10A4> ZAR1> FRYL< So, while the protein coding Zar1 gene (GeneID: 317755, MGI:2180337) of M. musculus isn't strictly the ortholog of the ZAR1 gene in other mammals the difference is trivial since it's restricted to a very small set of Mus-related organisms. The Slc10a4 gene of of M. musculus (GeneID: 231290, MGI:3606480) is a true ortholog of the gene in other mammals.
  • Genetic Map
    Chromosome 5, 38.44 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    193 from dbSNP Build 142
  • Strain Annotations
    12
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2180337
 protein coding gene Chr5:72734149-72738597 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029613
 protein coding gene Chr5:72500906-72518341 (-)
A/J MGP_AJ_G0029581
 protein coding gene Chr5:69815493-69819810 (-)
AKR/J no annotation
BALB/cJ MGP_BALBcJ_G0029598
 protein coding gene Chr5:70968687-70976065 (+)
C3H/HeJ MGP_C3HHeJ_G0029313
 protein coding gene Chr5:72385834-72401712 (-)
C57BL/6NJ no annotation
CAROLI/EiJ MGP_CAROLIEiJ_G0027284
 protein coding gene Chr5:65519199-65523363 (-)
CAST/EiJ MGP_CASTEiJ_G0028721
 protein coding gene Chr5:71516036-71520505 (-)
CBA/J MGP_CBAJ_G0029282
 protein coding gene Chr5:77915156-77928359 (-)
DBA/2J no annotation
FVB/NJ no annotation
LP/J no annotation
NOD/ShiLtJ MGP_NODShiLtJ_G0029423
 protein coding gene Chr5:81772276-81783475 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030085
 protein coding gene Chr5:72080695-72089872 (+)
PWK/PhJ MGP_PWKPhJ_G0028452
 protein coding gene Chr5:69278667-69285006 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028287
 protein coding gene Chr5:71432942-71438432 (+)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    ZAR1, zygote arrest 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZAR1, zygote arrest 1
  • Synonyms
    Z3CXXC6
  • Links
    NCBI Gene ID: 326340
    neXtProt AC: NX_Q86SH2
    UniProt: Q86SH2

  • Chr Location
    4p11; chr4:48490252-48497635 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 2 alleles in 3 genetic backgrounds
    5 phenotypes from multigenic genotypes
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Ovarian development and oogenesis are normal in homozygous null females; however, they are infertile due to a failure at the oocyte to embryo transition.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    775
  • Tissues
    26
  • cDNA Data
    12
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 317755 NCBI Gene Model | MGI Sequence Detail 3971 C57BL/6J ±  kb
    transcript NM_174877 RefSeq | MGI Sequence Detail 1284 C57BL/6  
    polypeptide Q80SU3 UniProt | EBI | MGI Sequence Detail 361 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 12
      Primer pair 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 11
      Gene Ontology 7
      Phenotypes 24
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:342865 Wan Y, et al., LSM14B is essential for oocyte meiotic maturation by regulating maternal mRNA storage and clearance. Nucleic Acids Res. 2023 Nov 27;51(21):11652-11667
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory