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Slc25a28 Gene Detail
Summary
  • Symbol
    Slc25a28
  • Name
    solute carrier family 25, member 28
  • Synonyms
    2210403D18Rik, Mfrn2, Mrs3/4
  • Feature Type
    protein coding gene
  • IDs
    MGI:2180509
    NCBI Gene: 246696
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:43652240-43663320 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 36.67 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    341 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2180509
 protein coding gene Chr19:43652240-43663320 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025154
 protein coding gene Chr19:43074197-43085217 (-)
A/J MGP_AJ_G0025131
 protein coding gene Chr19:41024735-41035807 (-)
AKR/J MGP_AKRJ_G0025099
 protein coding gene Chr19:42320156-42331174 (-)
BALB/cJ MGP_BALBcJ_G0025125
 protein coding gene Chr19:41067179-41078192 (-)
C3H/HeJ MGP_C3HHeJ_G0024885
 protein coding gene Chr19:42495847-42507798 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025568
 protein coding gene Chr19:44141744-44152773 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022982
 protein coding gene Chr19:40321827-40333213 (-)
CAST/EiJ MGP_CASTEiJ_G0024350
 protein coding gene Chr19:42190547-42202349 (-)
CBA/J MGP_CBAJ_G0024865
 protein coding gene Chr19:46325282-46339655 (-)
DBA/2J MGP_DBA2J_G0024997
 protein coding gene Chr19:40853247-40864265 (-)
FVB/NJ MGP_FVBNJ_G0024958
 protein coding gene Chr19:40607472-40618490 (-)
LP/J MGP_LPJ_G0025083
 protein coding gene Chr19:43041168-43052190 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024989
 protein coding gene Chr19:45874646-45885663 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025626
 protein coding gene Chr19:42412570-42423996 (-)
PWK/PhJ MGP_PWKPhJ_G0024099
 protein coding gene Chr19:40750281-40761394 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023903
 protein coding gene Chr19:41114442-41127416 (-)
WSB/EiJ MGP_WSBEiJ_G0024420
 protein coding gene Chr19:42550046-42561062 (-)



Homology
more
  • Human Ortholog
    SLC25A28, solute carrier family 25 member 28
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC25A28, solute carrier family 25 member 28
  • Synonyms
    MFRN2, MRS3/4, MRS4L, NPD016
  • Links
    NCBI Gene ID: 81894
    neXtProt AC: NX_Q96A46
    UniProt: Q96A46

  • Chr Location
    10q24.2; chr10:99610519-99659286 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 3 alleles in 3 genetic backgrounds
    4 phenotypes from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knockout results in reduced male fertility and exacerbates reduction of liver regeneration of hepatocyte specific Slc25a37 KO. Whole-body or hepatocyte specific KO affects iron metabolism and oxidative phosphorylation in liver mitochondria.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    722
  • Tissues
    16
  • cDNA Data
    55
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 246696 NCBI Gene Model | MGI Sequence Detail 11081 C57BL/6J ±  kb
    transcript NM_145156 RefSeq | MGI Sequence Detail 1569 ZRU/MplStud  
    polypeptide Q8R0Z5 UniProt | EBI | MGI Sequence Detail 364 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 58
      cDNA 57
      Primer pair 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:1922911
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 4
      Gene Ontology 9
      Phenotypes 17
    • Earliest
      J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory