Sertad3 MGI Mouse Gene Detail - MGI:2180697

Symbol

Sertad3
Name

SERTA domain containing 3
Synonyms

Rbt1, Sei3

Feature Type

protein coding gene
IDs

MGI:2180697
NCBI Gene: 170742
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr7:27173265-27176789 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 15.91 cM
Mapping Data

1 experiment

SNPs within 2kb

142 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2180697	protein coding gene	Chr7:27173193-27176789 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0031912	protein coding gene	Chr7:26130567-26134219 (+)
A/J	MGP_AJ_G0031891	protein coding gene	Chr7:25496817-25500415 (+)
AKR/J	MGP_AKRJ_G0031821	protein coding gene	Chr7:26179688-26183286 (+)
BALB/cJ	MGP_BALBcJ_G0031896	protein coding gene	Chr7:25714942-25718542 (+)
C3H/HeJ	MGP_C3HHeJ_G0031618	protein coding gene	Chr7:26554175-26557771 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0032361	protein coding gene	Chr7:26988569-26992165 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029413	protein coding gene	Chr7:26728237-26731900 (+)
CAST/EiJ	MGP_CASTEiJ_G0030953	protein coding gene	Chr7:19864680-19868326 (+)
CBA/J	MGP_CBAJ_G0031583	protein coding gene	Chr7:28183055-28186651 (+)
DBA/2J	MGP_DBA2J_G0031735	protein coding gene	Chr7:25296056-25299652 (+)
FVB/NJ	MGP_FVBNJ_G0031691	protein coding gene	Chr7:25396609-25400205 (+)
LP/J	MGP_LPJ_G0031815	protein coding gene	Chr7:26463662-26467314 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031726	protein coding gene	Chr7:27758314-27761910 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0032392	protein coding gene	Chr7:25713631-25717227 (+)
PWK/PhJ	MGP_PWKPhJ_G0030677	protein coding gene	Chr7:20332205-20335939 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0030511	protein coding gene	Chr7:16704590-16708243 (+)
WSB/EiJ	MGP_WSBEiJ_G0031061	protein coding gene	Chr7:25997753-26001345 (+)

Human Ortholog

SERTAD3, SERTA domain containing 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SERTAD3, SERTA domain containing 3
Synonyms

RBT1
Links

HGNC:17931

NCBI Gene ID: 29946

neXtProt AC: NX_Q9UJW9

UniProt: Q9UJW9
Chr Location

19q13.2; chr19:40440844-40444335 (-) GRCh38

MGI Vertebrate Homology

Sertad3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SERTAD3
Gene Tree

Sertad3

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Phenotype Summary

6 phenotypes from 2 alleles in 2 genetic backgrounds
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

19
Endonuclease-mediated

2
Gene trapped

16
Targeted

1
Find Mice (IMSR)

14 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous knockout increases susceptibility to RNA virus-induced morbidity and mortality.

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All GO Annotations

14
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

15
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase sertad3

ZFIN sertad3

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All Sequences

31
RefSeq

2
UniProt

2
CCDS

CCDS21021.1

Ensembl

ENSMUSG00000055200 (Evidence)
NCBI Gene

170742

			Length	Strain/Species	Flank
genomic	170742	NCBI Gene Model \| MGI Sequence Detail	3525	C57BL/6J	± kb
transcript	NM_133210	RefSeq \| MGI Sequence Detail	1356	C57BL/6
polypeptide	Q9ERC3	UniProt \| EBI \| MGI Sequence Detail	197	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000014713 SERTA domain-containing protein 3

(term hierarchy)
InterPro Domains

IPR009263 SERTA domain

IPR039585 SERTA domain-containing protein 3

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All nucleic 15

cDNA 15

Microarray probesets 4

Summaries

All 35

Developmental Gene Expression 1

Gene Ontology 6

Phenotypes 10
Earliest

J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Sertad3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr65280	Chr7:27173186-27173198 (+)	-73 bp
Tssr65281	Chr7:27173207-27173244 (+)	-39 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24