Gy Gene Detail

Summary

• Symbol
  Gy
• Name
  gyro deletion region

• Feature Type
  heritable phenotypic marker
• IDs
  MGI:2180716
  NCBI Gene: 246722
• Alliance
  gene page

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome X, Syntenic
• Mapping Data
  6 experiments

Human Diseases

• Diseases
  1 with Gy mouse models

Human Disease

Mouse Models

X-linked dominant hypophosphatemic rickets

IDs

X-linked dominant hypophosphatemic rickets      

DOID:0050445
MESH:D053098
NCI:C85234
OMIM:307800
UMLS_CUI:C0733682
UMLS_CUI:C1845168
UMLS_CUI:C3540852

View 1 model

Mouse Models

Human Disease Modeled: X-linked dominant hypophosphatemic rickets

Allelic Composition	Genetic Background	Reference	Phenotypes
Gy/Y	involves: C3H/Sn * C57BL/6Ei	J:38621 J:88352	View

Click on a disease name to see all genes associated with that disease.

• Mutations/Alleles
  1 with disease annotations

• References
  2 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  60 phenotypes from 1 allele in 5 genetic backgrounds
  25 phenotype references
  

• All Mutations and Alleles
  1
• Radiation induced
  1
• Find Mice (IMSR)
  1 strains or lines available

Hemizygous males for an irradiation-induced X-linked deletion that disrupts both Sms and Phex genes show the hypophosphatemic rickets (found also in mice with lone Phex mutations) but also exhibit reduced viability, circling behavior, markedly reduced spermine content, and sterility.

Sequences &
Gene Models

• NCBI Gene
  246722

References

• Summaries
  All 29

  Diseases 2

  Phenotypes 25
• Earliest
  J:28887 Carter TC, et al., The genetic sensitivity to X-rays of mouse foetal gonads. Genet Res. 1960;1(3):351-5
• Latest
  J:145570 Wang X, et al., Spermine synthase deficiency leads to deafness and a profound sensitivity to alpha-difluoromethylornithine. J Biol Chem. 2009 Jan 9;284(2):930-7